Evidence map›Paper›PMID 26735066›Full record

ArticleJournal of the American Chemical Society2016

Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O.

Chao Qi, Yuan Xiong, Vincent Eschenbrenner-Lux, Huan Cong, John A Porco

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Asymmetric Total Synthesis of (-)-Verrucarol.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chao QiDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University , Boston, Massachusetts 02215, United States.
Yuan XiongDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University , Boston, Massachusetts 02215, United States.
Vincent Eschenbrenner-LuxDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University , Boston, Massachusetts 02215, United States.
Huan CongDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University , Boston, Massachusetts 02215, United States.
John A PorcoDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University , Boston, Massachusetts 02215, United States.

Funding

Biomimetic Synthesis of Complex Natural ProductsR01GM073855 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PORCO, JOHN A. · 2006 to 2015
$3.2M
Center for Molecular Discovery (CMD): A Small Molecule Resource for Biomedical ResearchR24GM111625 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PORCO, JOHN A. · 2015 to 2017
$1.5M
Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural ProductsR01GM099920 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PORCO, JOHN A. · 2012 to 2015
$1.2M
NIGMS NIH HHS GM-073855NIGMS NIH HHS GM-099920NIGMS NIH HHS R01 GM073855NIGMS NIH HHS R01 GM099920NIGMS NIH HHS R24 GM111625NIGMS NIH HHS R24GM111625
6 · The paper itself

Abstract

Metal-catalyzed, double Claisen rearrangement of a bis-allyloxyflavone has been utilized to enable a concise synthesis of the hydrobenzofuro[3,2-b]chromenone core structure of the natural products sanggenon A and sanggenol F. In addition, catalytic, enantioselective [4+2] cycloadditions of 2'-hydroxychalcones have been accomplished using B(OPh)3/BINOL complexes. Asymmetric syntheses of the flavonoid Diels-Alder natural products sanggenons C and O have been achieved employing a stereodivergent reaction of a racemic mixture (stereodivergent RRM) involving [4+2] cycloaddition.

Indexed as

Cycloaddition ReactionBenzofuransBiological ProductsChromonesFlavonoidsMolecular StructureBenzofuransBiological ProductsChromonesFlavonoidssanggenone Csanggenon O

Identifiers

PMID26735066
PMCPMC4863937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.