ArticlePsychosomatic medicine2016
Modeling Multisystem Physiological Dysregulation.
Article in Psychosomatic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Allostatic Load in Cancer: A Systematic Review and Mini Meta-Analysis.Biological research for nursing · 2021Pooled it
- Relationship of Psychosocial Resources With Allostatic Load: A Systematic Review.Psychosomatic medicine · 2017Pooled it
- Mid-Trimester Allostatic Load and Spontaneous Preterm Birth in a Cohort of Pregnant Women Living with HIV in Zambia.Maternal and child health journal · 2025Trial
- Investigating associations between allostatic load phenotypes and clinical impairment in youth with chronic pain.Brain, behavior, & immunity - health · 2026Article
- The relationship between allostatic load levels and time to deterioration of health-related quality of life in non-small cell lung cancer patients.Journal of cancer survivorship : research and practice · 2026Article
- Assessing Measurement Invariance in Allostatic Load between Black and White Adolescents.Journal of racial and ethnic health disparities · 2026Article
- Disparities in Allostatic Load Among Different Races: A Comprehensive Scoping Review.Journal of racial and ethnic health disparities · 2025Review
- The impact of maternal chronic stress on spontaneous preterm birth: evidence from a Chinese cohort study.BMC pregnancy and childbirth · 2025Article
- The association between allostatic load and lymphedema in breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Affect regulation and allostatic load over time.Psychoneuroendocrinology · 2024Article
- The Interplay between Structural Inequality, Allostatic Load, Inflammation, and Cancer in Black Americans: A Narrative Review.Cancers · 2024Review
- Association of allostatic load with overall survival in epithelial ovarian cancer.Gynecologic oncology · 2024Observational
- Allostatic load as a predictor of postoperative complications in patients with breast cancer.NPJ breast cancer · 2024Article
- Association Between Neighborhood Opportunity, Allostatic Load, and All-Cause Mortality in Patients With Breast Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- The Implications of Racialized Economic Segregation and Allostatic Load on Mortality in Patients with Breast Cancer.Annals of surgical oncology · 2024Article
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- Allostatic load in children: The cost of empathic concern.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Association of Allostatic Load With All-Cause Mortality in Patients With Breast Cancer.JAMA network open · 2023Article
- Intercorrelated variability in blood and hemodynamic biomarkers reveals physiological network in hemodialysis patients.Scientific reports · 2023Article
- Applying minimally invasive biomarkers of chronic stress across complex ecological contexts.American journal of human biology : the official journal of the Human Biology Council · 2022Review
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Authors and funding
4 authors.
Funding
Abstract
objectivesThe purposes of this study were to compare the relative fit of two alternative factor models of allostatic load (AL) and physiological systems, and to test factor invariance across age and sex.
methodsData were from the Midlife in the United States II Biomarker Project, a large (n = 1255) multisite study of adults aged 34 to 84 years (56.8% women). Specifically, 23 biomarkers were included, representing seven physiological systems: metabolic lipids, metabolic glucose, blood pressure, parasympathetic nervous system, sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and inflammation. For factor invariance tests, age was categorized into three groups (≤45, 45-60, and >60 years).
resultsA bifactor model where biomarkers simultaneously load onto a common AL factor and seven unique system-specific factors provided the best fit to the biomarker data (comparative fit index = 0.967, root mean square error of approximation = 0.043, standardized root mean square residual = 0.028). Results from the bifactor model were consistent with invariance across age groups and sex.
conclusionsThese results support the theory that represents and operationalizes AL as multisystem physiological dysregulation and operationalizing AL as the shared variance across biomarkers. Results also demonstrate that in addition to the variance in biomarkers accounted for by AL, individual physiological systems account for unique variance in system-specific biomarkers. A bifactor model allows researchers greater precision to examine both AL and the unique effects of specific systems.
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