Observational studyAnais brasileiros de dermatologia
Clinical and histological study of permanent alopecia after bone marrow transplantation.
Observational study in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Alopecia following solid organ transplant: the Mayo Clinic experience.International journal of women's dermatology · 2026Article
- Alopecia in Children with Cancer: A Review from Pathophysiology to Management.American journal of clinical dermatology · 2025Review
- Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia.Stem cell research & therapy · 2024Article
- Hair loss during and after breast cancer therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Review
- Permanent chemotherapy-induced alopecia after hematopoietic stem cell transplantation treated with low-dose oral minoxidil.JAAD case reports · 2022Article
- Article
- Rapidly progressive diffuse fibrosing alopecia.JAAD case reports · 2019Article
- Hair disorders in cancer survivors.Journal of the American Academy of Dermatology · 2019Review
- Longstanding alopecia and nail dystrophy are associated with more severe overall chronic graft-versus-host disease in adults.Bone marrow transplantation · 2019Article
- Familial Cicatricial Alopecia: Report of Familial Frontal Fibrosing Alopecia and Fibrosing Alopecia in a Pattern Distribution.International journal of trichologyArticle
- Graft versus Host Disease Presenting as Fibrosing Alopecia in a Pattern Distribution: A Model for Pathophysiological Understanding of Cicatricial Pattern Hair Loss.International journal of trichologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPermanent alopecia after bone marrow transplantation is rare, but more and more cases have been described, typically involving high doses of chemotherapeutic agents used in the conditioning regimen for the transplant. Busulfan, classically described in cases of irreversible alopecia, remains associated in recent cases. The pathogenesis involved in hair loss is not clear and there are few studies available. In addition to chemotherapeutic agents, another factor that has been implicated as a cause is chronic graft-versus-host disease. However, there are no histopathological criteria for defining this diagnosis yet.
objectivethe study aims to evaluate clinical and histological aspects in cases of permanent alopecia after bone marrow transplantation, identifying features of permanent alopecia induced by myeloablative chemotherapy and alopecia as a manifestation of chronic graft-versus-host disease.
methodsdata were collected from medical records of 7 patients, with description of the clinical features and review of slides and paraffin blocks of biopsies.
resultsTwo distinct histological patterns were found: one similar to androgenetic alopecia, non-scarring pattern, and other similar to lichen planopilaris, scarring alopecia.
conclusionThe first pattern corroborates the literature cases of permanent alopecia induced by chemotherapeutic agents, and the second is compatible with manifestation of chronic graft-versus-host disease on scalp, that has never been described yet. The results contribute to the elucidation of the factors involved in these cases, including the development of therapeutic methods.
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