ArticleAmerican journal of respiratory and critical care medicine2016
Air Pollution and Lung Function in Minority Youth with Asthma in the GALA II (Genes-Environments and Admixture in Latino Americans) and SAGE II (Study of African Americans, Asthma, Genes, and Environments) Studies.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pooled it
- ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Pooled it
- Article
- The use of race and ethnicity in air pollution epidemiology and methodological recommendations: A scoping review focusing on California.Environmental epidemiology (Philadelphia, Pa.) · 2026Review
- Biomarkers of inflammation associated with radon exposure in the School Inner-City Asthma Study (SICAS).The Journal of allergy and clinical immunology · 2025Article
- Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children.Respiratory research · 2025Article
- Outdoor Air Pollution and Pediatric Respiratory Disease.Clinics in chest medicine · 2024Review
- A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.Nature communications · 2024Article
- Long-term ozone exposure and lung function in middle childhood.Environmental research · 2024Article
- EVALUATING THE RELATIONSHIPS BETWEEN GENETIC ANCESTRY AND THE CLINICAL PHENOME.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024Article
- Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells.Clinical epigenetics · 2023Article
- Influence of the environment on the characteristics of asthma.Scientific reports · 2022Article
- Article
- African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.Genome medicine · 2022Article
- Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology.Nature communications · 2022Article
- Long-term exposure to air pollution and lung function among children in China: Association and effect modification.Frontiers in public health · 2022Article
- Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.The Journal of allergy and clinical immunology · 2021Article
- Genetic ancestry differences in pediatric asthma readmission are mediated by socioenvironmental factors.The Journal of allergy and clinical immunology · 2021Article
- Air pollution and lung function in children.The Journal of allergy and clinical immunology · 2021Review
- Air quality, Environment and Respiratory Outcomes in Bronchopulmonary Dysplasia, the AERO-BPD cohort study: design and adaptation during the SARS-CoV-2 pandemic.BMJ open respiratory research · 2021Article
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Authors and funding
34 authors at 17 institutions in 5 countries.
Funding
Abstract
rationaleAdverse effects of exposures to ambient air pollution on lung function are well documented, but evidence in racial/ethnic minority children is lacking.
objectivesTo assess the relationship between air pollution and lung function in minority children with asthma and possible modification by global genetic ancestry.
methodsThe study population consisted of 1,449 Latino and 519 African American children with asthma from five different geographical regions in the mainland United States and Puerto Rico. We examined five pollutants (particulate matter ≤10 μm and ≤2.5 μm in diameter, ozone, nitrogen dioxide, and sulfur dioxide), derived from participant residential history and ambient air monitoring data, and assessed over several time windows. We fit generalized additive models for associations between pollutant exposures and lung function parameters and tested for interaction terms between exposures and genetic ancestry. MEASUREMENTS AND MAIN
resultsA 5 μg/m(3) increase in average lifetime particulate matter less than or equal to 2.5 μm in diameter exposure was associated with a 7.7% decrease in FEV1 (95% confidence interval = -11.8 to -3.5%) in the overall study population. Global genetic ancestry did not appear to significantly modify these associations, but percent African ancestry was a significant predictor of lung function.
conclusionsEarly-life particulate exposures were associated with reduced lung function in Latino and African American children with asthma. This is the first study to report an association between exposure to particulates and reduced lung function in minority children in which racial/ethnic status was measured by ancestry-informative markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.