ReviewFrontiers in medicine2015
Understanding the Impact of Infection, Inflammation, and Their Persistence in the Pathogenesis of Bronchopulmonary Dysplasia.
Review in Frontiers in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
131 citing papers in PubMed, 3 syntheses or guidelines pooled it, 214 citations in OpenAlex.
- Effects of postnatal corticosteroids on lung development in newborn animals. A systematic review.Pediatric research · 2024Pooled it
- Superoxide dismutase for bronchopulmonary dysplasia in preterm infants.The Cochrane database of systematic reviews · 2023Pooled it
- Academic performance of children born preterm: a meta-analysis and meta-regression.Archives of disease in childhood. Fetal and neonatal edition · 2018Pooled it
- The clinical value of lung ultrasound in premature infants with bronchopulmonary dysplasia.Revista da Associacao Medica Brasileira (1992) · 2023Trial
- Intranasal delivery of human umbilical cord Wharton's jelly mesenchymal stromal cells restores lung alveolarization and vascularization in experimental bronchopulmonary dysplasia.Stem cells translational medicine · 2020Trial
- The Mechano-Immune-Vascular Activation Loop: An Integrative Conceptual Framework for Positive Feedback in Hypertension.International journal of molecular sciences · 2026Review
- Epigenetic programming in bronchopulmonary dysplasia: a framework linking early-life exposures to persistent lung disease-a narrative review.Pediatric research · 2026Review
- Brain-derived neurotrophic factor (BDNF) in neonatal blood: associations with respiratory disease in extremely preterm infants.Pediatric research · 2026Article
- Ureaplasma positivity and respiratory outcomes in very low birth weight infants: a cohort study with a nested double-blind randomized pilot trial of azithromycin.BMC pediatrics · 2026Observational
- Perturbation of the preterm human immune system in early life.JCI insight · 2026Article
- Association between neonatal sepsis and lung function in school-age children born preterm.Pediatric research · 2026Article
- Lung Function Trajectories After Preterm Birth: A Life-Course Approach to Age-Specific Monitoring.Children (Basel, Switzerland) · 2026Review
- BPD prediction model for very preterm infants integrating chest X-ray scores within 7 days: a retrospective case-control study.BMJ open · 2026Article
- The Inflammatory Nexus of Bronchopulmonary Dysplasia: From Molecular Pathways to Precision Therapeutics.Mediators of inflammation · 2026Review
- Hospital-acquired infections in preterm infants with gestational age <32 weeks: a retrospective study of clinical characteristics, pathogen distribution, and associated factors.Frontiers in pediatrics · 2026Article
- Stage-specific neutrophil states in neonatal injury: from antimicrobial deficiency to pro-resolution repair.Frontiers in immunology · 2026Review
- Analysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Bronchopulmonary Dysplasia (BPD): A Study in the Polish Population.Current issues in molecular biology · 2025Article
- Whole blood biophysical immune profiling of newborn infants correlates with immune responses.Pediatric research · 2025Article
- MiR-203a-3p in extracellular vesicles derived from mesenchymal stem cells alleviates BPD-associated apoptosis and inflammation.Stem cell research & therapy · 2025Article
- Steroid Use for Established Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2025Review
71 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concerted interaction of genetic and environmental factors acts on the preterm human immature lung with inflammation being the common denominator leading to the multifactorial origin of the most common chronic lung disease in infants - -bronchopulmonary dysplasia (BPD). Adverse perinatal exposure to infection/inflammation with added insults like invasive mecha nical ventilation, exposure to hyperoxia, and sepsis causes persistent immune dysregulation. In this review article, we have attempted to analyze and consolidate current knowledge about the role played by persistent prenatal and postnatal inflammation in the pathogenesis of BPD. While some parameters of the early inflammatory response (neutrophils, cytokines, etc.) may not be detectable after days to weeks of exposure to noxious stimuli, they have already initiated the signaling pathways of the inflammatory process/immune cascade and have affected permanent defects structurally and functionally in the BPD lungs. Hence, translational research aimed at prevention/amelioration of BPD needs to focus on dampening the inflammatory response at an early stage to prevent the cascade of events leading to lung injury with impaired healing resulting in the pathologic pulmonary phenotype of alveolar simplification and dysregulated vascularization characteristic of BPD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.