ReviewJournal of cancer prevention2015
An Overview of Carcinogenic Heavy Metal: Molecular Toxicity Mechanism and Prevention.
Review in Journal of cancer prevention, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
191 citing papers in PubMed, 4 syntheses or guidelines pooled it, 659 citations in OpenAlex.
- Environmental Nonessential Element Exposure and Urologic Cancer: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Toxic Metal in Plant-Based Therapeutics: Contamination Pathways, Oxidative Stress Induction, and Onset of Disease.TheScientificWorldJournal · 2026Pooled it
- Unraveling the Puzzle: a Systematic Review of the Carcinogenic Role of Arsenic in Head and Neck Cancers.Biological trace element research · 2026Pooled it
- Heavy metals in biological samples of cancer patients: a systematic literature review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Pooled it
- Urinary KIM-1: a novel biomarker for evaluation of occupational exposure to lead.Scientific reports · 2016Trial
- Cadmium inhibits hSMUG1-mediated uracil excision: quantitative analysis and mitigation byJournal of enzyme inhibition and medicinal chemistry · 2026Article
- Associations between a mixture of trace elements and bladder cancer occurrence: A study of possible reverse causation.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Ascorbic and citric acids mitigate cadmium stress and reduce metal accumulation in spinach grown in alkaline calcareous soil.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Environmental Contaminants in Surface Snow Samples Made from Reclaimed Water at a Ski Resort: A Mass Spectrometry Analysis.ACS environmental Au · 2026Article
- Different types of voltametric techniques for selective and sensitive detection of heavy metal ions in wastewater system: a review.RSC advances · 2026Review
- Potential Toxic Elements in Farm Soils and Vegetables of Northern Bangladesh: Impact on Soil Health and Human Safety.Journal of xenobiotics · 2026Article
- Multi-metal cooperation drives chemoresistance in lung cancer and is reversed by the membrane-permeable chelator MiADMSA.Cell death discovery · 2026Article
- Elemental Profiling and Health Risk Assessment of Aromatic Oils Used for Oral and Topical Applications.Biological trace element research · 2026Article
- Trace Element Content in Fingernails of Vietnamese Men with Laryngeal Cancer: Cumulative Exposure Assessment.Biological trace element research · 2026Article
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Monte Carlo-Based Assessment of Toxic Metal Contaminations in Urban Agricultural Systems: A Case Study of Lead, Cadmium, and Copper in Vegetables and Fish from Nigeria.Biological trace element research · 2026Article
- Industrial point source emissions and incident breast and lung cancers: two case-control studies.Cancer causes & control : CCC · 2026Article
- Profiling of macroelements and microelements in colorectal cancer patients and their clinicopathological characteristics.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- In Vitro Bioaccessibility of Selenium in Popular Thai Seafood Across Cooking Methods.Foods (Basel, Switzerland) · 2026Article
- Toward Smart Salivary Diagnostics: A Comprehensive Review of Heavy Metal Biomarkers and Digital Risk Modeling.Diagnostics (Basel, Switzerland) · 2026Review
131 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost all heavy metals are serious toxicants as carcinogens. However, due to their chemical and physiological properties, heavy metals are useful in industrial areas including alloy, smelting and production of commercial products. Such applications increase the opportunity for heavy metal exposure. Waste from industrial processes is also a major source of environmental contamination and accumulation in the human body. Arsenic, cadmium, chromium, and nickel are classified as group 1 carcinogens by the International Agency for Research on Cancer, and are utilized commercially. In this review, we used molecular pathway analysis to understand the toxicity and carcinogenic mechanisms of these metals. Our analyzed data showed that above-mentioned metallic substances induce oxidative stress, DNA damage, and cell death processes, resulting in increase the risk of cancer and cancer-related diseases. Thus, we might think phytochelatin molecules and antioxidative phytochemical substances are helpful for prevention of heavy metal-induced cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.