ReviewFrontiers in cellular and infection microbiology2015
Salivary Antimicrobial Peptides in Early Detection of Periodontitis.
Review in Frontiers in cellular and infection microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Thermosensitive Hydrogels for Periodontal Regeneration: A Systematic Review of the Evidence.Clinical and experimental dental research · 2024Pooled it
- Mass Spectrometry-Based Proteomics for Discovering Salivary Biomarkers in Periodontitis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Wisdom across interfaces: Adhesion mechanism and application potential of wet-adhesive hydrogel in periodontal tissue.Bioactive materials · 2026Review
- Antimicrobial and Anti-Inflammatory Bioactive Peptides: Their Role in Potential Therapeutic Applications for Periodontitis-A Narrative Review.Nutrients · 2025Review
- Positive Role of Saliva in the Oral Microbiome.Advances in experimental medicine and biology · 2025Review
- Exploring the interplay of vitamin D, salivary antimicrobial peptides, and cytokines in oral immunity and disease prevention: an insight for implications in oral health policy.Frontiers in oral health · 2025Article
- Assesment of Salivary and Serum Levels of HBD2 in Patients with Chronic Angioedema.Journal of clinical medicine · 2024Article
- The Variability of the Salivary Antimicrobial Peptide Profile: Impact of Lifestyle.International journal of molecular sciences · 2024Review
- Systemic Factors Affecting Human Beta-Defensins in Oral Cavity.Pathogens (Basel, Switzerland) · 2024Review
- Oral microbiota and metabolites: key players in oral health and disorder, and microbiota-based therapies.Frontiers in microbiology · 2024Review
- Macrophages immunomodulation induced by Porphyromonas gingivalis and oral antimicrobial peptides.Odontology · 2023Review
- Mechanisms and regulation of defensins in host defense.Signal transduction and targeted therapy · 2023Review
- Functional biomaterials for comprehensive periodontitis therapy.Acta pharmaceutica Sinica. B · 2023Review
- The Potential Role of Epigenetic Modifications on Different Facets in the Periodontal Pathogenesis.Genes · 2023Review
- Proteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands.Clinical proteomics · 2023Article
- Review
- Antimicrobial peptide temporin derivatives inhibit biofilm formation and virulence factor expression ofFrontiers in microbiology · 2023Article
- Salivary levels of hBDs in children and adolescents with type 1 diabetes mellitus and gingivitis.Clinical oral investigations · 2022Article
- Antimicrobial peptides: Defending the mucosal epithelial barrier.Frontiers in oral health · 2022Review
- Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.Frontiers in oral health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the pathogenesis of periodontitis, an infection-induced inflammatory disease of the tooth-supporting tissues, there is a complex interaction between the subgingival microbiota and host tissues. A periodontal diagnostic tool for detecting the initiation and progression of the disease, monitoring the response to therapy, or measuring the degree of susceptibility to future disease progression has been of interest for a long time. The value of various enzymes, proteins, and immunoglobulins, which are abundant constituents of saliva, as potential biomarkers has been recognized and extensively investigated for periodontal diseases. Gingival defensins and cathelicidins are small cationic antimicrobial peptides that play an important role in innate immune response. However, their applicability as salivary biomarkers is still under debate. The present review focuses on proteomic biomarkers and antimicrobial peptides, in particular, to be used at early phases of periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.