ArticleBeilstein journal of nanotechnology2015
Ultrastructural changes in methicillin-resistant Staphylococcus aureus induced by positively charged silver nanoparticles.
Article in Beilstein journal of nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Integrating silver nanomaterials in wound healing: from physicochemical properties to clinical translation.Journal of nanobiotechnology · 2026Review
- Nanomaterial strategies for antibiotic-resistant infections: Mechanistic frameworks, rational design, and clinical translation.Materials today. Bio · 2026Review
- Assessment of silver ion disinfection in relation to microbial cell characteristics based on intrinsic quenching model.Journal of water and health · 2026Article
- Phytofabricated Farsetia aegyptia-derived silver nanoparticles mediate antibacterial and wound-healing activities in diabetic foot infection rat model.Inflammopharmacology · 2025Article
- Green synthesis of silver nanoparticles using Sudanese Candida parapsilosis: a sustainable approach to combat antimicrobial resistance.BMC microbiology · 2025Article
- Article
- Unlocking the Potential of Silver Nanoparticles: From Synthesis to Versatile Bio-Applications.Pharmaceutics · 2024Review
- Silver Nanoparticles: A Comprehensive Review of Synthesis Methods and Chemical and Physical Properties.Nanomaterials (Basel, Switzerland) · 2024Review
- Biogenic silver nanoparticle synthesis using orange peel extract and its multifaceted biomedical application.Bioprocess and biosystems engineering · 2024Article
- Myco-fabricated silver nanoparticle by novel soil fungi from Saudi Arabian desert and antimicrobial mechanism.Scientific reports · 2024Article
- Mycosynthesis of silver nanoparticles from endophyticFrontiers in microbiology · 2024Article
- Antimicrobial and Cytotoxic Activities of Water-Soluble Isoxazole-Linked 1,3,4-Oxadiazole with Delocalized Charge: In Vitro and In Vivo Results.International journal of molecular sciences · 2023Article
- Regulation ofPharmaceutics · 2023Review
- Silver Nanoparticle-Based Therapy: Can It Be Useful to Combat Multi-Drug Resistant Bacteria?Antibiotics (Basel, Switzerland) · 2022Review
- Emerging and future strategies in the management of recalcitrant Candida auris.Medical mycology · 2022Review
- Electrophoretic-deposited MXene titanium coatings in regulating bacteria and cell response for peri-implantitis.Frontiers in chemistry · 2022Article
- Soil Fungi as Biomediator in Silver Nanoparticles Formation and Antimicrobial Efficacy.International journal of nanomedicine · 2022Article
- Metal nanoparticles assisted revival of Streptomycin against MDRS Staphylococcus aureus.PloS one · 2022Article
- Preparation, Characterization and Antimicrobial Properties of Nanosized Silver-Containing Carbon/Silica Composites from Rice Husk Waste.ChemistryOpen · 2021Article
- Microbial Interkingdom Biofilms and the Quest for Novel Therapeutic Strategies.Microorganisms · 2021Review
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Authors and funding
8 authors.
Funding
Abstract
Silver nanoparticles offer a possible means of fighting antibacterial resistance. Most of their antibacterial properties are attributed to their silver ions. In the present work, we study the actions of positively charged silver nanoparticles against both methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. We use aberration-corrected transmission electron microscopy to examine the bactericidal effects of silver nanoparticles and the ultrastructural changes in bacteria that are induced by silver nanoparticles. The study revealed that our 1 nm average size silver nanoparticles induced thinning and permeabilization of the cell wall, destabilization of the peptidoglycan layer, and subsequent leakage of intracellular content, causing bacterial cell lysis. We hypothesize that positively charged silver nanoparticles bind to the negatively charged polyanionic backbones of teichoic acids and the related cell wall glycopolymers of bacteria as a first target, consequently stressing the structure and permeability of the cell wall. This hypothesis provides a major mechanism to explain the antibacterial effects of silver nanoparticles on Staphylococcus aureus. Future research should focus on defining the related molecular mechanisms and their importance to the antimicrobial activity of silver nanoparticles.
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