Evidence map›Paper›PMID 26734487›Full record

ReviewIranian Red Crescent medical journal2015

Occult HCV Infection: The Current State of Knowledge.

Mohammad Saeid Rezaee-Zavareh, Reza Hadi, Hamidreza Karimi-Sari, Mohammad Hossein Khosravi, Reza Ajudani, Fardin Dolatimehr, Mahdi Ramezani-Binabaj, Seyyed Mohammad Miri, Seyed Moayed Alavian

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Iranian Red Crescent medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. [Histological evaluation of liver in chronic hepatitis C after direct-acting antiviral agents treatment].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018
    Article
  12. Article
  13. Article
  14. Review
  15. Exploring Hepatitis From the Perspective of Iranian Traditional Medicine: Using a Qualitative Approach.Journal of evidence-based complementary & alternative medicine · 2017
    Review
  16. Article
  17. Article
  18. Hepatitis C virus: Promising discoveries and new treatments.World journal of gastroenterology · 2016
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mohammad Saeid Rezaee-ZavarehStudents' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran; Middle East Liver Diseases Center (MELD), Tehran, IR Iran.
Reza HadiMiddle East Liver Diseases Center (MELD), Tehran, IR Iran.
Hamidreza Karimi-SariStudents' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Mohammad Hossein KhosraviStudents' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Reza AjudaniStudents' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Fardin DolatimehrStudents' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Mahdi Ramezani-BinabajStudents' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Seyyed Mohammad MiriMiddle East Liver Diseases Center (MELD), Tehran, IR Iran; Kowsar Medical Institute, Heerlen, The Netherlands.
Seyed Moayed AlavianMiddle East Liver Diseases Center (MELD), Tehran, IR Iran; Baqiyatallah Research Center for Gasteroenterology and Liver Disease (BRCGL), Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Baqiyatallah University of Medical Sciences · IRMiddle East Liver Disease Center · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextOccult HCV infection (OCI) is defined as the presence of HCV-RNA in hepatocytes and the absence of HCV in the serum according to usual tests. We aimed to define OCI and provide information about the currently available diagnostic methods. Then we focus on specific groups that are at high risk of OCI and finally investigate immune responses to OCI and the available treatment approaches. EVIDENCE ACQUISITION: PubMed, Scopus and Google Scholar were comprehensively searched with combination of following keywords: "occult", "hepatitis C virus" and "occult HCV infection". The definition of OCI, diagnostic methods, specific groups that are at high risk and available treatment approaches were extract from literature. An analysis of available articles on OCI also was done based on Scopus search results.

resultsOCI has been reported in several high-risk groups, especially in hemodialysis patients and subjects with cryptogenic liver disease. Furthermore, some studies have proposed a specific immune response for OCI in comparison with chronic hepatitis C (CHC).

conclusionsWith a clinical history of approximately 11 years, occult HCV infection can be considered an occult type of CHC. Evidences suggest that considering OCI in these high-risk groups seems to be necessary. We suggest that alternative diagnostic tests should be applied and that there is a need for the participation of all countries to determine the epidemiology of this type of HCV infection. Additionally, evaluating OCI in blood transfusion centers and in patients who receive large amounts of blood and clotting factors, such as patients with hemophilia, should be performed in future projects.

Indexed as

Hepatitis CKnowledgeOccult infectionReview

Identifiers

PMID26734487
PMCPMC4698335
OpenAlexW2103354395

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.