Evidence map›Paper›PMID 26734469›Full record

ArticleIranian Red Crescent medical journal2015

Immunohistochemical Assessment of HER3 Expression in Odontogenic Cysts.

Marieh Honarmand, Shirin Saravani, Nazanin Kamyab, Mehdi Jahantigh, Molouk Torabi Parizi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian Red Crescent medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Marieh HonarmandOral and Dental Disease Research Centre, Department of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, IR Iran.
Shirin SaravaniOral and Dental Disease Research Centre, Department of Oral and Maxillofacial Pathology, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, IR Iran.
Nazanin KamyabDepartment of Oral Medicine, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran.
Mehdi JahantighDepartment of Pathology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.
Molouk Torabi PariziDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Kerman University of Medical Sciences, Kerman, IR Iran.
Zahedan University of Medical Sciences · IRKerman University of Medical Sciences · IRRafsanjan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been demonstrated that HER3 plays an important role in some human cancers and the HER3 expression is associated with worse survival in solid tumors.

objectivesThis study was conducted to compare HER3 expression in epithelial lining of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). MATERIALS AND

methodsThis was a descriptive-analytical study, which assessed all 57 paraffin blocks of RCs, DCs and OKCs (21 RCs, 16 DCs, 20 OKC) from pathological archive of Dentistry College of Zahedan, Iran. The HER3 expression in cytoplasm and membrane was examined by immunohistochemical method. The data collected was analyzed using SPSS16 by ANOVA and Chi-square. P < 0.05 was considered as statistically significant.

resultsThe HER3 expression had positive results in 52.4% of OKC, 50% of DC and only 20% of RC samples. There was a significant difference between HER3 expression in OKCs and RCs.

conclusionsThe HER3 expression in developmental odontogenic cysts was higher than that in inflammatory odontogenic cysts. The higher rate of HER3 expression in OKC may justify inherent growth potential, stimulation-independent proliferation capability, invasive growth and high recurrence rate of the cyst accepted today as a tumor.

Indexed as

Dentigerous CystHuman Epidermal Growth Factor Receptor3Odontogenic CystsRadicular Cyst

Identifiers

PMID26734469
PMCPMC4698317
OpenAlexW2112650367

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