ArticleBiomicrofluidics2015
Assessment of the biocompatibility of three-dimensional-printed polymers using multispecies toxicity tests.
Article in Biomicrofluidics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Augmented 3D Printing for Multiscale Microphysiological Systems.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Recent Developments and Applications of 3D-Printing Technology in Pharmaceutical Drug Delivery Systems: A New Research Direction and Future Trends.Current pharmaceutical design · 2025Review
- Unlocking the potential of 3D printed microfluidics for mass spectrometry analysis using liquid infused surfaces.Analytica chimica acta · 2023Article
- Assessing Leachable Cytotoxicity of 3D-Printed Polymers and Facile Detoxification Methods.3D printing and additive manufacturing · 2023Article
- Biocompatible High-Resolution 3D-Printed Microfluidic Devices: Integrated Cell Chemotaxis Demonstration.Micromachines · 2023Article
- Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications.Lab on a chip · 2023Review
- Hydrogel-Assisted Double Molding Enables Rapid Replication of Stereolithographic 3D Prints for Engineered Tissue Design.ACS applied materials & interfaces · 2023Article
- A 'print-pause-print' protocol for 3D printing microfluidics using multimaterial stereolithography.Nature protocols · 2023Review
- Initial assessment of the toxicologic effects of leachates from 3-dimensional (3-D) printed objects on sperm quality in two model fish species.Aquatic toxicology (Amsterdam, Netherlands) · 2023Article
- Direct 3D printed biocompatible microfluidics: assessment of human mesenchymal stem cell differentiation and cytotoxic drug screening in a dynamic culture system.Journal of nanobiotechnology · 2022Article
- Tailoring the composition of biocopolyester blends for dimensionally accurate extrusion-based printing, annealing and steam sterilization.Scientific reports · 2022Article
- 3D-Printed PLA Medical Devices: Physicochemical Changes and Biological Response after Sterilisation Treatments.Polymers · 2022Article
- Cytotoxicity of polymers intended for the extrusion-based additive manufacturing of surgical guides.Scientific reports · 2022Article
- Compatibility of Popular Three-Dimensional Printed Microfluidics Materials with In Vitro Enzymatic Reactions.ACS applied bio materials · 2022Article
- A millifluidic chip for cultivation of fish embryos and toxicity testing fabricated by 3D printing technology.RSC advances · 2021Article
- Class II biocompatible E-Shell 300 3D printing material causes severe developmental toxicity inRSC advances · 2021Article
- Study of Microchannels Fabricated Using Desktop Fused Deposition Modeling Systems.Micromachines · 2020Article
- Biocompatibility of Blank, Post-Processed and Coated 3D Printed Resin Structures with Electrogenic Cells.Biosensors · 2020Article
- 3D Printing of Cell Culture Devices: Assessment and Prevention of the Cytotoxicity of Photopolymers for Stereolithography.Materials (Basel, Switzerland) · 2020Article
- Digital Manufacturing for Microfluidics.Annual review of biomedical engineering · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Additive manufacturing was adopted in multiple fields of life sciences. It is also becoming a popular tool for rapid prototyping of microfluidic and biomedical devices. Limited studies have been performed to investigate the biological implications of using 3D printed polymers. Here we assessed the biocompatibility of seven commercially available polymers, using a battery of standardized bioassays for chemical risk assessment. Our data show that leachates from photopolymers substrata appear to be very toxic to vertebrates and several invertebrate indicator organisms. These results demonstrate significant consequences for the use of selected photopolymers in the fabrication of bio-devices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.