ArticleAIDS research and therapy2016
Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests.
Article in AIDS research and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
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- A 43-year-old man with an indeterminate HIV test.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- HIV testing algorithm using fourth generation reagents reduces the false positive rate of screening tests.Scientific reports · 2025Article
- Analysis of Increased False-Positive ELISA Results for HIV in the Blood of Donors Infected with SARS-CoV-2.Bulletin of experimental biology and medicine · 2025Article
- Evaluation of a new human immunodeficiency virus antigen and antibody test using light-initiated chemiluminescent assay.Frontiers in cellular and infection microbiology · 2025Article
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- Utility of the Signal-to-Cutoff Ratio and Antigen Index from Fourth- and Fifth-Generation HIV-1/HIV-2 Antigen/Antibody Assays for the Diagnosis of Acute HIV Infection: Applicability for Real-Time Use for Immediate Initiation of Antiretroviral Therapy.Journal of clinical microbiology · 2022Article
- A fatal SARS-coronavirus-2 induced bone marrow aplasia complicated with invasive fungal infection and severe neutropenic enterocolitis.BMC infectious diseases · 2022Article
- Clinical Application Evaluation of ElecsysFrontiers in cellular and infection microbiology · 2022Article
- Evaluation of serological assays for the diagnosis of HIV infection in adults.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2021Article
- Cross-reactivity of SARS-CoV-2 with HIV chemiluminescent assay leading to false-positive results.Journal of clinical pathology · 2021Article
- False reactive HIV-1 diagnostic test results in an individual from Kenya on multiple testing platforms-A case report.IDCases · 2021Article
- The evaluation of low cut-off index values of ElecsysJournal of clinical laboratory analysis · 2020Article
- Repeated false reactive ADVIA centaur® and bio-rad Geenius™ HIV tests in a patient self-administering anabolic steroids.BMC infectious diseases · 2020Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Novel fourth generation screening and confirmatory human immunodeficiency virus (HIV) assays are now commercially available and incorporated into new diagnostic algorithms. We report two cases involving a total of three patients which highlight the spectrum of false positivity for both the Abbott Architect p24 antigen/antibody assay and the confirmatory Multispot antibody differentiation test. We then discuss the mechanisms for false positivity and the associated clinical conditions or laboratory scenarios that may predispose to inaccurate interpretation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.