ArticleFrontiers in plant science2015
Insect Herbivory-Elicited GABA Accumulation in Plants is a Wound-Induced, Direct, Systemic, and Jasmonate-Independent Defense Response.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 107 citations in OpenAlex.
- Herbivory-induced metabolic reprogramming in soybean cultivars contrasting in resistance to Bemisia tabaci MEAM1.Journal of insect science (Online) · 2026Article
- Transcriptomics and trans-organellar complementation reveal limited signaling of 12-cis-oxo-phytodienoic acid during early wound response in Arabidopsis.Nature communications · 2025Article
- Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana.Nature communications · 2025Article
- Cost-effective production ofBiology methods & protocols · 2025Article
- GABA does not regulate stomatal CO2 signalling in Arabidopsis.Journal of experimental botany · 2024Article
- GABA transport: beyond stress? A closer look at AtGAT2.Journal of experimental botany · 2024Article
- Augmenting Rice Defenses: Exogenous Calcium Elevates GABA Levels Against WBPH Infestation.Antioxidants (Basel, Switzerland) · 2024Article
- Relationship between the GABA Pathway and Signaling of Other Regulatory Molecules.International journal of molecular sciences · 2024Review
- Development of super-infective ternary vector systems for enhancing theHorticulture research · 2024Article
- Emerging Trends in Non-Protein Amino Acids as Potential Priming Agents: Implications for Stress Management Strategies and Unveiling Their Regulatory Functions.International journal of molecular sciences · 2024Review
- The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat.Science advances · 2024Article
- Gamma-aminobutyric acid treatment promotes resistance againstFrontiers in plant science · 2024Article
- Comprehensive analysis of silicon impact on defense and metabolic responses in rice exposed to herbivory stress.Frontiers in plant science · 2024Article
- An Enzyme Assay Kit for GABA Quantification in Plant Tissues.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Gamma-Aminobutyric Acid Accumulation Contributes toPlants (Basel, Switzerland) · 2023Article
- Gamma-Aminobutyric Acid Supplementation Boosts the Phytohormonal Profile in 'Plants (Basel, Switzerland) · 2023Article
- NMR-Based Metabolomics: A New Paradigm to Unravel Defense-Related Metabolites in Insect-Resistant Cotton Variety through Different Multivariate Data Analysis Approaches.Molecules (Basel, Switzerland) · 2023Article
- The nitrogen-dependent GABA pathway of tomato provides resistance to a globally invasive fruit fly.Frontiers in plant science · 2023Article
- Article
- Pseudomonas syringae pv. tomato infection of tomato plants is mediated by GABA and l-Pro chemoperception.Molecular plant pathology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The non-proteinogenic amino acid γ-aminobutyric acid (GABA) is present in all organisms analyzed so far. In invertebrates GABA acts as a neurotransmitter; in plants different functions are under discussion. Among others, its involvement in abiotic stress reactions and as a defensive compound against feeding insects is suggested. GABA is synthesized from glutamate by glutamate decarboxylases and degraded by GABA-transaminases. Here, in Arabidopsis thaliana, gad1/2 double mutants showing reduced GABA concentrations as well as GABA-enriched triple mutants (gad1/2 x pop2-5) were generated and employed for a systematic study of GABA induction, accumulation and related effects in Arabidopsis leaves upon herbivory. The results demonstrate that GABA accumulation is stimulated by insect feeding-like wounding by a robotic caterpillar, MecWorm, as well as by real insect (Spodoptera littoralis) herbivory. Higher GABA levels in both plant tissue and artificial dietary supplements in turn affect the performance of feeding larvae. GABA enrichment occurs not only in the challenged but also in adjacent leaf. This induced response is neither dependent on herbivore defense-related phytohormones, jasmonates, nor is jasmonate induction dependent on the presence of GABA. Thus, in Arabidopsis the rapid accumulation of GABA very likely represents a general, direct and systemic defense reaction against insect herbivores.
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