Evidence map›Paper›PMID 26733993›Full record

ReviewFrontiers in microbiology2015

Fungal Melanin: What do We Know About Structure?

Joshua D Nosanchuk, Ruth E Stark, Arturo Casadevall

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 301 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Impact of Drought on Cereals Infected withPathogens (Basel, Switzerland) · 2026
    Review
  7. Dismantling darkness: interdisciplinary perspectives on melanin degradation.World journal of microbiology & biotechnology · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. From melanogenesis to melanin technologies.Communications chemistry · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Identification and functional characterization of major geneApplied and environmental microbiology · 2025
    Article
  18. Article
  19. Future microbiology · 2025
    Review
  20. Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Joshua D NosanchukDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of MedicineBronx, NY, USA; Microbiology and Immunology, Albert Einstein College of MedicineBronx, NY, USA.
Ruth E StarkDepartment of Chemistry and Biochemistry, The Graduate Center, The City College of New York, The City University of New YorkNew York, NY, USA; Institute for Macromolecular Assemblies, The City University of New YorkNew York, NY, USA.
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University Baltimore, MD, USA.
Albert Einstein College of Medicine · USJohns Hopkins University · USThe Graduate Center, CUNY · US

Funding

TNC FUNCTION IN APOPTOTIC ANTIGEN DRIVEN AUTOIMMUNITYG12RR003060 · NCRR · CITY COLLEGE OF NEW YORK · PI WALLMAN, JOSHUA · 1985 to 2011
$26.1M
Cellular/Molecular Basis of Development: Research CenterG12MD007603 · NIMHD · CITY COLLEGE OF NEW YORK · PI PEZZANO, MARK · 2012 to 2017
$11.5M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
NCRR NIH HHS G12 RR003060NIAID NIH HHS R01 AI052733NIMHD NIH HHS G12 MD007603
6 · The paper itself

Abstract

The production of melanin significantly enhances the virulence of many important human pathogenic fungi. Despite fungal melanin's importance in human disease, as well as melanin's contribution to the ability of fungi to survive in diverse hostile environments, the structure of melanin remains unsolved. Nevertheless, ongoing research efforts have progressively revealed several notable structural characteristics of this enigmatic pigment, which will be the focus of this review. These compositional and organizational insights could further our ability to develop novel therapeutic approaches to combat fungal disease and enhance our understanding of how melanin is inserted into the cell wall.

Indexed as

cryptococcusfungal virulencefungimelaninstructure

Identifiers

PMID26733993
PMCPMC4687393
OpenAlexW2243082285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.