ArticleFrontiers in physiology2015
Low Intensity Exercise Training Improves Skeletal Muscle Regeneration Potential.
Article in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Protective effect of exercise on animals with sepsis: a systematic review of the existing literature.BMC infectious diseases · 2025Pooled it
- Epigenetic Modifications as Outcomes of Exercise Interventions Related to Specific Metabolic Alterations: A Systematic Review.Lifestyle genomics · 2019Pooled it
- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- Broadband Electrical Spectroscopy to Distinguish Single-Cell CaSensors (Basel, Switzerland) · 2023Article
- Restoring Epigenetic Reprogramming with Diet and Exercise to Improve Health-Related Metabolic Diseases.Biomolecules · 2023Review
- Metabolic correlates to critical speed in murine models of sickle cell disease.Frontiers in physiology · 2023Article
- Signatures of Mitochondrial Dysfunction and Impaired Fatty Acid Metabolism in Plasma of Patients with Post-Acute Sequelae of COVID-19 (PASC).Metabolites · 2022Article
- Aging and Possible Benefits or Negatives of Lifelong Endurance Running: How Master Male Athletes Differ from Young Athletes and Elderly Sedentary?International journal of environmental research and public health · 2022Article
- New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin.Frontiers in physiology · 2022Article
- Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure.Journal of cachexia, sarcopenia and muscle · 2020Article
- Novel Mechanisms of Exercise-Induced Cardioprotective Factors in Myocardial Infarction.Frontiers in physiology · 2020Review
- Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure.Iranian journal of basic medical sciences · 2018Article
- The Bottom-Up Rise Strength Transfer in Elderly After Endurance and Resistance Training: The BURST.Frontiers in physiology · 2018Article
- Superoxide Anion Production and Bioenergetic Profile in Young and Elderly Human Primary Myoblasts.Oxidative medicine and cellular longevity · 2018Article
- Extracellular Guanosine 5'-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine.Frontiers in pharmacology · 2018Article
- Physiological effects of high-altitude trekking on gonadal, thyroid hormones and macrophage migration inhibitory factor (MIF) responses in young lowlander women.Physiological reports · 2017Article
- Rejuvenating stem cells to restore muscle regeneration in aging.F1000Research · 2017Review
- The Regenerative Potential of Female Skeletal Muscle upon Hypobaric Hypoxic Exposure.Frontiers in physiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to determine whether 12 days of low-to-moderate exercise training at low altitude (598 m a.s.l.) improves skeletal muscle regeneration in sedentary adult women.
methodsSatellite cells were obtained from the vastus lateralis skeletal muscle of seven women before and after this exercise training at low altitude. They were investigated for differentiation aspects, superoxide anion production, antioxidant enzymes, mitochondrial potential variation after a depolarizing insult, intracellular Ca(2+) concentrations, and micro (mi)RNA expression (miR-1, miR-133, miR-206).
resultsIn these myogenic populations of adult stem cells, those obtained after exercise training, showed increased Fusion Index and intracellular Ca(2+) concentrations. This exercise training also generally reduced superoxide anion production in cells (by 12-67%), although not in two women, where there was an increase of ~15% along with a reduced superoxide dismutase activity. miRNA expression showed an exercise-induced epigenetic transcription profile that was specific according to the reduced or increased superoxide anion production of the cells.
conclusionsThe present study shows that low-to-moderate exercise training at low altitude improves the regenerative capacity of skeletal muscle in adult women. The differentiation of cells was favored by increased intracellular calcium concentration and increased the fusion index. This low-to-moderate training at low altitude also depicted the epigenetic signature of cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.