ArticleFrontiers in aging neuroscience2015
Patterns of Age-Associated Degeneration Differ in Shoulder Muscles.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Phantomless calibration of glenoid trabecular bone density: improved accuracy using age-stratified reference tissue densities.JBMR plus · 2026Article
- Site-specific myopathy differences between spine and limb muscles: a kyphotic TSC1mKO mice model study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Influence of Pain on Rotator Cuff Muscle Size and Function: A Case-Control Study with Ultrasound Assessment of Cross-Sectional Area and Tendon Thickness.International journal of sports physical therapy · 2026Article
- Ten-Year Outcomes of Modular Reverse Shoulder Arthroplasty Assessed by 3D Motion Analysis.Therapeutics and clinical risk management · 2026Article
- Exploring age-related differences in asymptomatic male shoulder kinematics using four-dimensional computed tomography.JSES international · 2026Article
- Arthroscopic intra-articular vs. subpectoral biceps tenodesis with concomitant rotator cuff repair leads to equivocal MCID achievement.JSES international · 2025Article
- Older age is associated with decreased overall shoulder strength but not direction-specific differences in the three-dimensional feasible torque space.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2024Article
- Long-term outcomes of pectoralis major transfer for scapular winging due to long thoracic nerve palsy: results after a median follow-up of 17 years.JSES international · 2024Article
- Serial Changes of Fatty Degeneration and Clinical Outcomes after Repair of Medium-Sized Rotator Cuff Tears.Clinics in orthopedic surgery · 2024Article
- Emerging Role of Quantitative Ultrasound-Based Imaging Techniques for Characterizing Rotator Cuff Tears: A Scoping Review.Diagnostics (Basel, Switzerland) · 2023Article
- Supraspinatus muscle atrophy in relation to aging with or without shoulder pathology: A radiographic study.Journal of clinical orthopaedics and trauma · 2023Article
- Quantitative analysis of myofiber type composition in human and mouse skeletal muscles.STAR protocols · 2023Article
- Article
- A unique sarcopenic progression in the mouse rotator cuff.Journal of cachexia, sarcopenia and muscle · 2022Article
- The metabolic landscape in chronic rotator cuff tear reveals tissue-region-specific signatures.Journal of cachexia, sarcopenia and muscle · 2022Article
- Shoulder movement complexity in the aging shoulder: A cross-sectional analysis and reliability assessment.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Characterization of Infraspinatus Tendon Anatomy: The Soft-Tissue Portion of Remplissage.Arthroscopy, sports medicine, and rehabilitation · 2021Article
- Age Differences in Motor Recruitment Patterns of the Shoulder in Dynamic and Isometric Contractions. A Cross-Sectional Study.Journal of clinical medicine · 2021Article
- Quantitative Ultrasonographic Analysis of Changes of the Suprascapular Nerve in the Aging Population With Shoulder Pain.Frontiers in bioengineering and biotechnology · 2021Article
- Prognostic factors for the outcome of needle aspiration of calcific deposits for rotator cuff calcific tendinitis.European radiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shoulder complaints are common in the elderly and hamper daily functioning. These complaints are often caused by tears in the muscle-tendon units of the rotator cuff (RC). The four RC muscles stabilize the shoulder joint. While some RC muscles are frequently torn in shoulder complaints others remain intact. The pathological changes in RC muscles are poorly understood. We investigated changes in RC muscle pathology combining radiological and histological procedures. We measured cross sectional area (CSA) and fatty infiltration from Magnetic Resonance Imaging with Arthrography (MRA) in subjects without (N = 294) and with (N = 109) RC-tears. Normalized muscle CSA of the four RC muscles and the deltoid shoulder muscle were compared and age-associated patterns of muscle atrophy and fatty infiltration were constructed. We identified two distinct age-associated patterns: in the supraspinatus and subscapularis RC muscles CSAs continuously declined throughout adulthood, whereas in the infraspinatus and deltoid reduced CSA was prominent from midlife onwards. In the teres minor, CSA was unchanged with age. Most importantly, age-associated patterns were highly similar between subjects without RC tear and those with RC-tears. This suggests that extensive RC muscle atrophy during aging could contribute to RC pathology. We compared muscle pathology between torn infraspinatus and non-torn teres minor and the deltoid in two patients with a massive RC-tear. In the torn infraspinatus we found pronounced fatty droplets, an increase in extracellular collagen-1, a loss of myosin heavy chain-1 expression in myofibers and an increase in Pax7-positive cells. However, the adjacent intact teres minor and deltoid exhibited healthy muscle features. This suggests that satellite cells and the extracellular matrix may contribute to extensive muscle fibrosis in torn RC. We suggest that torn RC muscles display hallmarks of muscle aging whereas the teres minor could represent an aging-resilient muscle.
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