ArticleFrontiers in neuroinformatics2015
Spike Detection for Large Neural Populations Using High Density Multielectrode Arrays.
Article in Frontiers in neuroinformatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
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- Photostimulation improves maturation of human photoreceptors.Nature communications · 2026Article
- Nitric oxide refines retinal circuit architecture independently of retinal wave dynamics.Cell death discovery · 2026Article
- Retinal Electrical Synapses Prime Neighbor Cells to Amplify Looming Related Threat Signals and Support Escape Behavior.Research square · 2026Article
- Microelectrode arrays cultured with in vitro neural networks for motion control tasks: encoding and decoding progress and advances.Microsystems & nanoengineering · 2025Review
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Article
- Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli.PLoS computational biology · 2025Article
- AECuration: automated event curation for spike sorting.Journal of neural engineering · 2025Article
- A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina.Nature communications · 2025Article
- Enhanced electrophysiological recordings in acute brain slices, spheroids, and organoids using 3D high-density multielectrode arrays.PloS one · 2025Article
- Unsupervised spike sorting for multielectrode arrays based on spike shape features and location methods.Biomedical engineering letters · 2024Article
- Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.iScience · 2024Article
- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light.iScience · 2023Article
- Stimulation-mediated reverse engineering of silent neural networks.Journal of neurophysiology · 2023Article
- Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids.Journal of cellular and molecular medicine · 2023Article
- Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina.Stem cells translational medicine · 2022Article
- A novel approach to the functional classification of retinal ganglion cells.Open biology · 2022Article
- A novel machine learning-based approach for the detection and analysis of spontaneous synaptic currents.PloS one · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
An emerging generation of high-density microelectrode arrays (MEAs) is now capable of recording spiking activity simultaneously from thousands of neurons with closely spaced electrodes. Reliable spike detection and analysis in such recordings is challenging due to the large amount of raw data and the dense sampling of spikes with closely spaced electrodes. Here, we present a highly efficient, online capable spike detection algorithm, and an offline method with improved detection rates, which enables estimation of spatial event locations at a resolution higher than that provided by the array by combining information from multiple electrodes. Data acquired with a 4096 channel MEA from neuronal cultures and the neonatal retina, as well as synthetic data, was used to test and validate these methods. We demonstrate that these algorithms outperform conventional methods due to a better noise estimate and an improved signal-to-noise ratio (SNR) through combining information from multiple electrodes. Finally, we present a new approach for analyzing population activity based on the characterization of the spatio-temporal event profile, which does not require the isolation of single units. Overall, we show how the improved spatial resolution provided by high density, large scale MEAs can be reliably exploited to characterize activity from large neural populations and brain circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.