ArticleFrontiers in behavioral neuroscience2015
Could Stress Contribute to Pain-Related Fear in Chronic Pain?
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- An investigation of the effect of smartphone-based pain management application on pain intensity and the quality-of-life dimensions in adolescents with chronic pain: a cluster randomized parallel-controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Trial
- The effect of a smartphone-based pain management application on pain intensity and quality of life in adolescents with chronic pain.Scientific reports · 2021Trial
- Fear of pain and cortisol reactivity predict the strength of stress-induced hypoalgesia.European journal of pain (London, England) · 2018Trial
- Review
- Autonomic cardiovascular mechanisms linked to stress in dental practice.British dental journal · 2026Review
- Fear-Avoidance Beliefs for Physical Activity Among Chronic Low Back Pain: A Multicenter Cross-Sectional Study.Journal of pain research · 2023Article
- Acquisition learning is stronger for aversive than appetitive events.Communications biology · 2022Article
- The Good, the Bad, and the Ugly-Chances, Challenges, and Clinical Implications of Avoidance Research in Psychosomatic Medicine.Frontiers in psychiatry · 2022Review
- Associative learning and extinction of conditioned threat predictors across sensory modalities.Communications biology · 2021Article
- Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome.Neural plasticity · 2021Article
- Neuromagnetic Amygdala Response to Pain-Related Fear as a Brain Signature of Fibromyalgia.Pain and therapy · 2020Article
- Differential Alterations in Cortico-Amygdala Circuitry in Mice with Impaired Fear Extinction.Molecular neurobiology · 2020Article
- The interaction between stress and chronic pain through the lens of threat learning.Neuroscience and biobehavioral reviews · 2019Review
- An Integrative Neuroscience Framework for the Treatment of Chronic Pain: From Cellular Alterations to Behavior.Frontiers in integrative neuroscience · 2018Article
- The stress concept in gastroenterology: from Selye to today.F1000Research · 2017Review
- [Psychobiological mechanisms in the pathophysiology of chronic visceral pain].Schmerz (Berlin, Germany) · 2016Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning to predict pain based on internal or external cues constitutes a fundamental and highly adaptive process aimed at self-protection. Pain-related fear is an essential component of this response, which is formed by associative and instrumental learning processes. In chronic pain, pain-related fear may become maladaptive, drive avoidance behaviors and contribute to symptom chronicity. Pavlovian fear conditioning has proven fruitful to elucidate associative learning and extinction involving aversive stimuli, including pain, but studies in chronic pain remain scarce. Stress demonstrably exerts differential effects on emotional learning and memory processes, but this has not been transferred to pain-related fear. Within this perspective, we propose that stress could contribute to impaired pain-related associative learning and extinction processes and call for interdisciplinary research. Specifically, we suggest to test the hypotheses that: (1) extinction-related phenomena inducing a re-activation of maladaptive pain-related fear (e.g., reinstatement, renewal) likely occur in everyday life of chronic pain patients and may alter pain processing, impair perceptual discrimination and favor overgeneralization; (2) acute stress prior to or during acquisition of pain-related fear may facilitate the formation and/or consolidation of pain-related fear memories; (3) stress during or after extinction may impair extinction efficacy resulting in greater reinstatement or context-dependent renewal of pain-related fear; and (4) these effects could be amplified by chronic stress due to early adversity and/or psychiatric comorbidity such depression or anxiety in patients with chronic pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.