ArticleFrontiers in neuroanatomy2015
Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects.
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Article in Frontiers in neuroanatomy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
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37 citing papers in PubMed, 67 citations in OpenAlex.
- Characterizing Interthalamic Adhesion Morphology in Schizophrenia: Associations With Aging, Neuropsychological Functioning, and Atypical Hippocampal Development.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Presence, Severity, and Functional Associations of Incomplete Hippocampal Inversion in 22q11.2 Deletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Hippocampal malformation in Dravet syndrome.Epilepsia · 2026Review
- Minor Physical Anomalies and Congenital Malformations Among Children with Psychotic Symptoms: An Exploratory Descriptive Study with Illustrative Clinical Cases.Brain sciences · 2026Article
- Hippocampal volume in affective and non-affective psychosis.Schizophrenia research · 2025Article
- Balancing Efficacy and Safety: Transcranial Direct Current Stimulation as an Adjunctive Intervention for Persistent Auditory Verbal Hallucinations in a Case of Schizophrenia and Seizure Disorder with Incomplete Hippocampal Inversion.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Automatic rating of incomplete hippocampal inversions evaluated across multiple cohorts.ArXiv · 2025Article
- 3D histological mapping of hippocampal subfields: a comparative study in patients with schizophrenia and healthy controls.Frontiers in psychiatry · 2025Article
- Microdeletion 1p32p31 Presenting with Moyamoya Disease and Incomplete Hippocampal Inversion.Molecular syndromology · 2024Article
- Smaller anterior hippocampal subfields in the early stage of psychosis.Translational psychiatry · 2024Article
- Attention-gated 3D CapsNet for robust hippocampal segmentation.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Neural correlates of transient topographical disorientation: an experimental EEG-MRI case study.Journal of neurology · 2023Article
- Deep phenotyping of the neuroimaging and skeletal features in KBG syndrome: a study of 53 patients and review of the literature.Journal of medical genetics · 2023Review
- Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability.Brain structure & function · 2023Article
- ComBat Harmonization: Empirical Bayes versus fully Bayes approaches.NeuroImage. Clinical · 2023Article
- Incomplete Hippocampal Inversion: A Neurodevelopmental Mechanism for Hippocampal Shape Deformation in Schizophrenia.Biological psychiatry · 2022Article
- High Incidence of Hippocampal Abnormalities in Pediatric Patients with Congenital Cytomegalovirus Infection.Neuropediatrics · 2022Article
- Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models.International journal of molecular sciences · 2022Review
- Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths.Neuropathology and applied neurobiology · 2022Article
- FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts.Human brain mapping · 2022Review
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Authors and funding
35 authors at 17 institutions in 7 countries.
Claire CuryInstitut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France; Centre d'Acquisition et de Traitement des ImagesParis, France.
Roberto ToroCentre National de la Recherche Scientifique, Genes, Synapses and Cognition, URA 2182, Institut PasteurParis, France; Human Genetics and Cognitive Functions, Institut PasteurParis, France.
Fanny CohenInstitut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France.
Clara FischerCentre d'Acquisition et de Traitement des ImagesParis, France; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du VivantGif-Sur-Yvette, France.
Amel MhayaInstitut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France.
Jorge Samper-GonzálezInstitut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France.
Dominique HasbounInstitut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France; Departments of Neuroradiology and Neurology, AP-HP, Hôpital de la Pitié-SalpétrièreParis, France.
Jean-François ManginCentre d'Acquisition et de Traitement des ImagesParis, France; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du VivantGif-Sur-Yvette, France.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Clinical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine, Trinity College DublinDublin, Ireland; Institute of Neuroscience, Trinity College DublinDublin, Ireland.
Uli BrombergDepartment of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf Hamburg, Germany.
Christian BuechelDepartment of Systems Neuroscience, Universitätsklinikum Hamburg EppendorfHamburg, Germany; Department of Psychology, Stanford UniversityStanford, CA, USA.
Anna CattrellInstitute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; MRC Social, Genetic and Developmental Psychiatry CentreLondon, UK.
Patricia ConrodInstitute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; Département de Psychiatrie, Centre Hospitalier Universitaire Sainte-Justine, Université de MontrealMontreal, QC, Canada.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University Mannheim, Germany.
Juergen GallinatDepartment of Systems Neuroscience, Universitätsklinikum Hamburg EppendorfHamburg, Germany; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin BerlinGermany.
Hugh GaravanDiscipline of Psychiatry, School of Medicine, Trinity College Dublin Dublin, Ireland.
Penny GowlandSchool of Physics and Astronomy, University of Nottingham Nottingham, UK.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt Berlin, Germany.
Hervé LemaitreInstitut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes Paris, France.
Jean-Luc MartinotInstitut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes Paris, France.
Frauke NeesDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University Mannheim, Germany.
Marie-Laure Paillère MartinotInstitut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris DescartesParis, France; AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, University Paris Descartes, Sorbonne Paris CitéParis, France.
Dimitri P OrfanosInstitut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du Vivant Gif-Sur-Yvette, France.
Tomas PausRotman Research Institute, BaycrestToronto, ON, Canada; Departments of Psychology and Psychiatry, University of TorontoToronto, Canada; Center for Developing Brain, Child Mind InstituteNew York, NY, USA.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Clinical Faculty Mannheim, Central Institute of Mental Health, University of HeidelbergMannheim, Germany; Department of Child and Adolescent Psychiatry, Medical University of ViennaVienna, Austria.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden Dresden, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin BerlinGermany; Berlin School of Mind and Brain, Humboldt University BerlinBerlin, Germany.
Robert WhelanDepartment of Psychology, University College Dublin Dublin, Ireland.
Vincent FrouinInstitut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du Vivant Gif-Sur-Yvette, France.
Gunter SchumannInstitute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; MRC Social, Genetic and Developmental Psychiatry CentreLondon, UK.
Joan A GlaunèsMAP5, Université Paris Descartes, Sorbonne Paris Cité Paris, France.
Olivier ColliotInstitut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du Cerveau et de la Moelle épinière, Institut du Cerveau et de la Moelle épinièreParis, France; Inria, Aramis Team, Centre de Recherche Paris-RocquencourtParis, France; Centre d'Acquisition et de Traitement des ImagesParis, France; Departments of Neuroradiology and Neurology, AP-HP, Hôpital de la Pitié-SalpétrièreParis, France.
IMAGEN Consortium
Institut national de recherche en sciences et technologies du numérique · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHeidelberg University · DEKing's College London · GBUniversité Paris-Sud · FREppendorf (Germany) · DETrinity College Dublin · IECentre National de la Recherche Scientifique · FRCharité - Universitätsmedizin Berlin · DEDélégation Paris 5 · FRHumboldt-Universität zu Berlin · DEPhysikalisch-Technische Bundesanstalt · DETechnische Universität Dresden · DEUniversity College Dublin · IEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Nottingham · GBUniversity of Toronto · CA
Funding
Medical Research Council G0901858
Abstract
The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left: 17%, right: 6%, χ(2)-test, p < 10(-28)). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.
Indexed as
anatomical variabilitybrain developmentcortical sulcihuman hippocampusIMAGEN databaseLarge databasemalrotationMRI
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