Evidence map›Paper›PMID 26733816›Full record

ReviewFrontiers in cellular neuroscience2015

Precocious Alterations of Brain Oscillatory Activity in Alzheimer's Disease: A Window of Opportunity for Early Diagnosis and Treatment.

Valentine Hamm, Céline Héraud, Jean-Christophe Cassel, Chantal Mathis, Romain Goutagny

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Aberrant Medial Prefrontal Cortex Activity and Flexible Behavior in the TgF344-AD Rat Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  5. Review
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  13. Amyloid, APP, and Electrical Activity of the Brain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2020
    Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Valentine HammCentre National de la Recherche Scientifique UMR 7364, Laboratoire de Neurosciences Cognitives et AdaptativesStrasbourg, France; Université de Strasbourg, Neuropôle de StrasbourgStrasbourg, France.
Céline HéraudCentre National de la Recherche Scientifique UMR 7364, Laboratoire de Neurosciences Cognitives et AdaptativesStrasbourg, France; Université de Strasbourg, Neuropôle de StrasbourgStrasbourg, France.
Jean-Christophe CasselCentre National de la Recherche Scientifique UMR 7364, Laboratoire de Neurosciences Cognitives et AdaptativesStrasbourg, France; Université de Strasbourg, Neuropôle de StrasbourgStrasbourg, France.
Chantal MathisCentre National de la Recherche Scientifique UMR 7364, Laboratoire de Neurosciences Cognitives et AdaptativesStrasbourg, France; Université de Strasbourg, Neuropôle de StrasbourgStrasbourg, France.
Romain GoutagnyCentre National de la Recherche Scientifique UMR 7364, Laboratoire de Neurosciences Cognitives et AdaptativesStrasbourg, France; Université de Strasbourg, Neuropôle de StrasbourgStrasbourg, France.
Laboratoire de Neurosciences Cognitives et Adaptatives · FRUniversité de Strasbourg · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of neurodegenerative dementia accounting for 50-80% of all age-related dementia. This pathology is characterized by the progressive and irreversible alteration of cognitive functions, such as memory, leading inexorably to the loss of autonomy for patients with AD. The pathology is linked with aging and occurs most commonly around 65 years old. Its prevalence (5% over 65 years of age and 20% after 80 years) constitutes an economic and social burden for AD patients and their family. At the present, there is still no cure for AD, actual treatments being moderately effective only in early stages of the pathology. A lot of efforts have been deployed with the aim of defining new AD biomarkers. Successful early detection of mild cognitive impairment (MCI) linked to AD requires the identification of biomarkers capable of distinguishing individuals with early stages of AD from other pathologies impacting cognition such as depression. In this article, we will review recent evidence suggesting that electroencephalographic (EEG) recordings, coupled with behavioral assessments, could be a useful approach and easily implementable for a precocious detection of AD.

Indexed as

Alzheimer’s diseaseelectroencephalographymild cognitive impairmentoscillatory activityrecognition memoryspatial navigation memory

Identifiers

PMID26733816
PMCPMC4685112
OpenAlexW2233467756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.