ReviewFrontiers in cellular neuroscience2015
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue.
Review in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- Editorial: Understanding of brain cellular dysfunction in psychiatric disorders-relevant phenotypes: from humans to models.Frontiers in psychiatry · 2024Article
- Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination.Molecular psychiatry · 2022Article
- In Vitro Recapitulation of Neuropsychiatric Disorders with Pluripotent Stem Cells-Derived Brain Organoids.International journal of environmental research and public health · 2021Review
- Article
- Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex.The international journal of neuropsychopharmacology · 2021Article
- Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness.Translational psychiatry · 2021Article
- The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression.Molecular neurobiology · 2020Review
- Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2020Review
- Progress in iPSC-Based Modeling of Psychiatric Disorders.International journal of molecular sciences · 2019Review
- Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population.Schizophrenia bulletin · 2019Article
- Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage.International journal of molecular sciences · 2019Review
- Altered serum levels of glial cell line-derived neurotrophic factor in male chronic schizophrenia patients with tardive dyskinesia.International journal of methods in psychiatric research · 2018Article
- Myths and truths about the cellular composition of the human brain: A review of influential concepts.Journal of chemical neuroanatomy · 2018Review
- Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder.Translational psychiatry · 2018Article
- Article
- Lactate in the brain: from metabolic end-product to signalling molecule.Nature reviews. Neuroscience · 2018Review
- Structural Neuroimaging of Anorexia Nervosa: Future Directions in the Quest for Mechanisms Underlying Dynamic Alterations.Biological psychiatry · 2018Review
- Effects of Monoamines and Antidepressants on Astrocyte Physiology: Implications for Monoamine Hypothesis of Depression.Journal of experimental neuroscience · 2018Review
- Extend, Pathomechanism and Clinical Consequences of Brain Volume Changes in Anorexia Nervosa.Current neuropharmacology · 2018Review
- Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders.Current opinion in neurobiology · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mental illnesses have long been perceived as the exclusive consequence of abnormalities in neuronal functioning. Until recently, the role of glial cells in the pathophysiology of mental diseases has largely been overlooked. However recently, multiple lines of evidence suggest more diverse and significant functions of glia with behavior-altering effects. The newly ascribed roles of astrocytes, oligodendrocytes and microglia have led to their examination in brain pathology and mental illnesses. Indeed, abnormalities in glial function, structure and density have been observed in postmortem brain studies of subjects diagnosed with mental illnesses. In this review, we discuss the newly identified functions of glia and highlight the findings of glial abnormalities in psychiatric disorders. We discuss these preclinical and clinical findings implicating the involvement of glial cells in mental illnesses with the perspective that these cells may represent a new target for treatment.
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