ArticleFrontiers in neuroscience2015
Inter-Individual Responses to Experimental Muscle Pain: Baseline Physiological Parameters Do Not Determine Whether Muscle Sympathetic Nerve Activity Increases or Decreases During Pain.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Relationship between muscle sympathetic nerve activity and rapid increases in circulating leukocytes during experimental muscle pain.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Heart Rate Variability and Pain: A Systematic Review.Brain sciences · 2022Review
- Cutaneous warmth, but not touch, increases muscle sympathetic nerve activity during a muscle fatigue hand-grip task.Experimental brain research · 2020Article
- The effects of audiovisual distraction on the muscle sympathetic responses to experimental muscle pain.Experimental brain research · 2018Article
- Muscle sympathetic nerve activity-coupled changes in brain activity during sustained muscle pain.Brain and behavior · 2018Article
- Cardiovascular autonomic regulation, inflammation and pain in rheumatoid arthritis.Autonomic neuroscience : basic & clinical · 2017Observational
- In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis.Molecules (Basel, Switzerland) · 2017Article
- Central circuitry responsible for the divergent sympathetic responses to tonic muscle pain in humans.Human brain mapping · 2017Article
- Sympathetic Responses to Noxious Stimulation of Muscle and Skin.Frontiers in neurology · 2016Review
- Pain perception: predictive value of sex, depression, anxiety, somatosensory amplification, obesity, and age.Neuropsychiatric disease and treatment · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously reported that there are inter-individual differences in the cardiovascular responses to experimental muscle pain, which are consistent over time: intramuscular infusion of hypertonic saline, causing pain lasting ~60 min, increases muscle sympathetic nerve activity (MSNA)-as well as blood pressure and heart rate-in certain subjects, but decrease it in others. Here, we tested the hypothesis that baseline physiological parameters (resting MSNA, heart rate, blood pressure, heart rate variability) determine the cardiovascular responses to long-lasting muscle pain. MSNA was recorded from the common peroneal nerve, together with heart rate and blood pressure, during a 45-min intramuscular infusion of hypertonic saline solution into the tibialis anterior of 50 awake human subjects (25 females and 25 males). Twenty-four subjects showed a sustained increase in mean amplitude of MSNA (160.9 ± 7.3%), while 26 showed a sustained decrease (55.1 ± 3.5%). Between the increasing and decreasing groups there were no differences in baseline MSNA (19.0 ± 1.5 vs. 18.9 ± 1.2 bursts/min), mean BP (88.1 ± 5.2 vs. 88.0 ± 3.8 mmHg), HR (74.7 ± 2.0 vs. 72.8 ± 1.8 beats/min) or heart rate variability (LF/HF 1.8 ± 0.2 vs. 2.2 ± 0.3). Furthermore, neither sex nor body mass index had any effect on whether MSNA increased or decreased during tonic muscle pain. We conclude that the measured baseline physiological parameters cannot account for the divergent sympathetic responses during tonic muscle pain.
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