ArticleJournal of experimental botany2016
The plastidial retrograde signal methyl erythritol cyclopyrophosphate is a regulator of salicylic acid and jasmonic acid crosstalk.
Article in Journal of experimental botany, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Vestigial Plastids in Parasitic Plants: Evolutionary Remnants or Adaptive Innovations?Plant, cell & environment · 2026Review
- Metabolite control of enzyme activity links stress to biosynthetic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An evolutionarily conserved metabolite inhibits biofilm formation in Escherichia coli K-12.Nature communications · 2024Article
- Deoxyxylulose 5-Phosphate Synthase Does Not Play a Major Role in Regulating the Methylerythritol 4-Phosphate Pathway in Poplar.International journal of molecular sciences · 2024Article
- Arabidopsis TGA256 Transcription Factors Suppress Salicylic-Acid-Induced Sucrose Starvation.Plants (Basel, Switzerland) · 2023Article
- HDR, the last enzyme in the MEP pathway, differently regulates isoprenoid biosynthesis in two woody plants.Plant physiology · 2023Article
- Methyl Jasmonate Activates theMolecules (Basel, Switzerland) · 2022Article
- Chloroplast ROS and stress signaling.Plant communications · 2022Review
- Melatonin-Mediated Abiotic Stress Tolerance in Plants.Frontiers in plant science · 2022Review
- Function of Chloroplasts in Plant Stress Responses.International journal of molecular sciences · 2021Review
- Negative regulation of plastidial isoprenoid pathway by herbivore-induced β-cyclocitral inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- NbTMP14 Is Involved in Tomato Spotted Wilt Virus Infection and Symptom Development by Interaction with the Viral NSm Protein.Viruses · 2021Article
- TheFrontiers in plant science · 2021Article
- Retrograde Induction of phyB Orchestrates Ethylene-Auxin Hierarchy to Regulate Growth.Plant physiology · 2020Article
- Chloroplast-associated molecular patterns as concept for fine-tuned operational retrograde signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Organellar protein multi-functionality and phenotypic plasticity in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Uncovering the functional residues ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Orthogonal regulation of phytochrome B abundance by stress-specific plastidial retrograde signaling metabolite.Nature communications · 2019Article
- The plastidial metabolite 2-C-methyl-D-erythritol-2,4-cyclodiphosphate modulates defence responses against aphids.Plant, cell & environment · 2019Article
- Waterlogging tolerance rendered by oxylipin-mediated metabolic reprogramming in Arabidopsis.Journal of experimental botany · 2019Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The exquisite harmony between hormones and their corresponding signaling pathways is central to prioritizing plant responses to simultaneous and/or successive environmental trepidations. The crosstalk between jasmonic acid (JA) and salicylic acid (SA) is an established effective mechanism that optimizes and tailors plant adaptive responses. However, the underlying regulatory modules of this crosstalk are largely unknown. Global transcriptomic analyses of mutant plants (ceh1) with elevated levels of the stress-induced plastidial retrograde signaling metabolite 2-C-methyl-D-erythritol cyclopyrophosphate (MEcPP) revealed robustly induced JA marker genes, expected to be suppressed by the presence of constitutively high SA levels in the mutant background. Analyses of a range of genotypes with varying SA and MEcPP levels established the selective role of MEcPP-mediated signal(s) in induction of JA-responsive genes in the presence of elevated SA. Metabolic profiling revealed the presence of high levels of the JA precursor 12-oxo-phytodienoic acid (OPDA), but near wild type levels of JA in the ceh1 mutant plants. Analyses of coronatine-insensitive 1 (coi1)/ceh1 double mutant plants confirmed that the MEcPP-mediated induction is JA receptor COI1 dependent, potentially through elevated OPDA. These findings identify MEcPP as a previously unrecognized central regulatory module that induces JA-responsive genes in the presence of high SA, thereby staging a multifaceted plant response within the environmental context.
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