ArticleProceedings of the National Academy of Sciences of the United States of America2016
Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- NLX-112 Randomized Phase 2A Trial: Safety, Tolerability, Anti-Dyskinetic, and Anti-Parkinsonian Efficacy.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- Targeting GCell reports. Medicine · 2026Article
- Synchronous activation of striatal cholinergic interneurons induces local serotonin release.Nature communications · 2026Article
- Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward.Nature communications · 2026Article
- The Serotonin 1B Receptor Modulates Striatal Activity Differentially Based on Behavioral Context.eNeuro · 2026Article
- Power Spectral Slope as a Novel Brain Functional Marker for Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- Neurotoxic effects of chronic ethanol on cholinergic interneurons in the dorsomedial striatum.Neuropharmacology · 2026Article
- The serotonin 1B receptor modulates striatal activity differentially based on behavioral context.bioRxiv : the preprint server for biology · 2025Article
- Distribution of Serotonergic Transporter Innervation in the Nucleus Accumbens and Ventral Pallidum Is Highly Conserved Among Primates.The Journal of comparative neurology · 2025Article
- Ethanol inhibits dorsomedial striatum acetylcholine release.bioRxiv : the preprint server for biology · 2025Article
- Projections from ventral hippocampus to nucleus accumbens' cholinergic neurons are altered in depression.The Journal of general physiology · 2025Article
- Extrinsic and intrinsic control of striatal cholinergic interneuron activity.Frontiers in molecular neuroscience · 2025Review
- Darbepoetin alpha has an anxiolytic and anti-neuroinflammatory effect in male rats.BMC immunology · 2024Article
- Striatal Serotonin Release Signals Reward Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function.Cell & bioscience · 2024Article
- The nucleus accumbens in reward and aversion processing: insights and implications.Frontiers in behavioral neuroscience · 2024Review
- Adult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging.Molecular psychiatry · 2023Article
- Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice.Nature communications · 2023Article
- Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo.Journal of neurochemistry · 2023Review
- Indoleamine 2, 3-dioxygenase is responsible for low stress tolerance after intracerebral hemorrhage.PloS one · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known about the molecular similarities and differences between neurons in the ventral (vSt) and dorsal striatum (dSt) and their physiological implications. In the vSt, serotonin [5-Hydroxytryptamine (5-HT)] modulates mood control and pleasure response, whereas in the dSt, 5-HT regulates motor behavior. Here we show that, in mice, 5-HT depolarizes cholinergic interneurons (ChIs) of the dSt whereas hyperpolarizing ChIs from the vSt by acting on different 5-HT receptor isoforms. In the vSt, 5-HT1A (a postsynaptic receptor) and 5-HT1B (a presynaptic receptor) are highly expressed, and synergistically inhibit the excitability of ChIs. The inhibitory modulation by 5-HT1B, but not that by 5-HT1A, is mediated by p11, a protein associated with major depressive disorder. Specific deletion of 5-HT1B from cholinergic neurons results in impaired inhibition of ACh release in the vSt and in anhedonic-like behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.