ArticleProceedings of the National Academy of Sciences of the United States of America2016
Mice plan decision strategies based on previously learned time intervals, locations, and probabilities.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
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- Mice extrapolate temporal information based on previously learned spatiotemporal mappings: An asymmetrical case.Learning & behavior · 2026Article
- Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group-individual strategies.Frontiers in neuroscience · 2026Article
- Environmental dynamics impact whether matching is optimal.PNAS nexus · 2026Article
- Foraging animals use dynamic Bayesian updating to model meta-uncertainty in environment representations.PLoS computational biology · 2025Article
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- Harmonization of the fastest and densest responses reflects humanlike reaction time in mice.Frontiers in neuroscience · 2025Article
- Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice.bioRxiv : the preprint server for biology · 2024Article
- Sex similarities and dopaminergic differences in interval timing.Behavioral neuroscience · 2024Article
- Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations.bioRxiv : the preprint server for biology · 2024Article
- Mice make temporal inferences about novel locations based on previously learned spatiotemporal contingencies.Animal cognition · 2023Article
- Glycolysis-enhancing αNPJ Parkinson's disease · 2023Article
- Count-based decision-making in mice: numerosity vs. stimulus control.Animal cognition · 2022Article
- Mice expressing P301S mutant human tau have deficits in interval timing.Behavioural brain research · 2022Article
- Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Article
- Rodents monitor their error in self-generated duration on a single trial basis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Experience-related enhancements in striatal temporal encoding.The European journal of neuroscience · 2021Article
- Numerical averaging in mice.Animal cognition · 2021Article
- Probabilistic Information Modulates the Timed Response Inhibition Deficit in Aging Mice.Frontiers in behavioral neuroscience · 2019Article
- An approach to monitoring home-cage behavior in mice that facilitates data sharing.Nature protocols · 2018Article
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3 authors.
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Abstract
Animals can shape their timed behaviors based on experienced probabilistic relations in a nearly optimal fashion. On the other hand, it is not clear if they adopt these timed decisions by making computations based on previously learnt task parameters (time intervals, locations, and probabilities) or if they gradually develop their decisions based on trial and error. To address this question, we tested mice in the timed-switching task, which required them to anticipate when (after a short or long delay) and at which of the two delay locations a reward would be presented. The probability of short trials differed between test groups in two experiments. Critically, we first trained mice on relevant task parameters by signaling the active trial with a discriminative stimulus and delivered the corresponding reward after the associated delay without any response requirement (without inducing switching behavior). During the test phase, both options were presented simultaneously to characterize the emergence and temporal characteristics of the switching behavior. Mice exhibited timed-switching behavior starting from the first few test trials, and their performance remained stable throughout testing in the majority of the conditions. Furthermore, as the probability of the short trial increased, mice waited longer before switching from the short to long location (experiment 1). These behavioral adjustments were in directions predicted by reward maximization. These results suggest that rather than gradually adjusting their time-dependent choice behavior, mice abruptly adopted temporal decision strategies by directly integrating their previous knowledge of task parameters into their timed behavior, supporting the model-based representational account of temporal risk assessment.
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