ArticleClinical cancer research : an official journal of the American Association for Cancer Research2016
A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected Colorectal Cancer Liver Metastases.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Distant Metastasis in Colorectal Cancer Patients-Do We Have New Predicting Clinicopathological and Molecular Biomarkers? A Comprehensive Review.International journal of molecular sciences · 2020Pooled it
- Systematic Review of the Prognostic Role of the Immune System After Surgery of Colorectal Liver Metastases.Frontiers in oncology · 2019Pooled it
- SBRT for Liver Tumors: What the Interventional Radiologist Needs to Know.Seminars in interventional radiology · 2024Review
- Application of Nanoparticles in the Diagnosis and Treatment of Colorectal Cancer.Anti-cancer agents in medicinal chemistry · 2024Review
- Nomogram for predicting occurrence and prognosis of liver metastasis in elderly colorectal cancer patients: a population-based study.Frontiers in oncology · 2023Article
- A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy.NPJ precision oncology · 2022Article
- Nomogram Predicting the Survival of Young-Onset Patients with Colorectal Cancer Liver Metastases.Diagnostics (Basel, Switzerland) · 2022Article
- The Future of ctDNA-Defined Minimal Residual Disease: Personalizing Adjuvant Therapy in Colorectal Cancer.Clinical colorectal cancer · 2022Review
- Molecular Determinants and Other Factors to Guide Selection of Patients for Hepatic Resection of Metastatic Colorectal Cancer.Current treatment options in oncology · 2021Review
- Development of KAM score to predict metastasis and worse survival in breast cancer.American journal of cancer research · 2021Article
- Modern therapeutic approaches for the treatment of malignant liver tumours.Nature reviews. Gastroenterology & hepatology · 2020Review
- Towards precision medicine in colorectal cancer liver metastases.Hepatic oncology · 2020Article
- B Cells as Prognostic Biomarker After Surgery for Colorectal Liver Metastases.Frontiers in oncology · 2020Article
- Thermal Ablation of Metastatic Colon Cancer to the Liver.Seminars in interventional radiology · 2019Review
- Overexpression of CASC19 indicates poor prognosis and facilitates proliferation, migration and invasion in colorectal cancer.Translational cancer research · 2019Article
- Impact of Genetics on Neoadjuvant Therapy with Complete Pathological Response in Metastatic Colorectal Cancer: Case Report and Review of the Literature.Balkan journal of medical genetics : BJMG · 2019Article
- Colorectal liver metastases: An update on multidisciplinary approach.World journal of hepatology · 2019Review
- Genome-Wide Scan for Copy Number Alteration Association with Relapse-Free Survival in Colorectal Cancer with Liver Metastasis Patients.Journal of clinical medicine · 2018Article
- The role of selective internal radiotherapy with Y-90 resin microsphere in first-line therapy for hepatic colorectal metastases.Hepatobiliary surgery and nutrition · 2018Article
- Genetic And Morphological Evaluation (GAME) score for patients with colorectal liver metastases.The British journal of surgery · 2018Article
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16 authors.
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Abstract
purposeRisk stratification after surgery for colorectal cancer liver metastases (CRLM) is achieved using clinicopathologic variables, however, is of limited accuracy. We sought to derive and externally validate a multigene expression assay prognostic of overall survival (OS) that is superior to clinicopathologic variables in patients with surgically resected CRLM. EXPERIMENTAL
designWe measured mRNA expression in prospectively collected frozen tumor from 96 patients with surgically resected CRLM at Memorial Sloan Kettering Cancer Center (MSKCC, New York, NY). We retrospectively generated a 20-gene molecular risk score (MRS) and compared its prognostic utility for OS and recurrence-free survival (RFS) with three common clinical risk scores (CRS). We then tested the prognostic ability of the MRS in an external validation cohort (European) of 119 patients with surgically resected CRLM at the University Medical Center Utrecht (Utrecht, the Netherlands) and Paul Brousse Hospital (Villejuif, France).
resultsFor OS in the MSKCC cohort, MRS was the strongest independent prognosticator (HR, 3.7-4.9; P < 0.001) followed by adjuvant chemotherapy (HR, 0.3; P ≤ 0.001). For OS in the European cohort, MRS was the only independent prognosticator (HR, 3.5; P = 0.007). For RFS, MRS was also independently prognostic in the MSKCC cohort (HR, 2.4-2.6; P ≤ 0.001) and the European cohort (HR, 1.6-2.5; P ≤ 0.05).
conclusionsCompared with CRSs, the MRS is more accurate, broadly applicable, and an independent prognostic biomarker of OS in resected CRLM. This MRS is the first externally validated prognostic multigene expression assay after metastasectomy for CRLM and warrants prospective validation. Clin Cancer Res; 22(10); 2575-82. ©2016 AACR.
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