Evidence map›Paper›PMID 26733563›Full record

Trial reportBMJ open2016

Acupuncture point injection treatment of primary dysmenorrhoea: a randomised, double blind, controlled study.

C Wade, L Wang, W J Zhao, F Cardini, F Kronenberg, S Q Gui, Z Ying, N Q Zhao, M T Chao, J Yu

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00104546 (Vitamin K Injection Treatment for Primary Dysmenorrhea), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00104546 phase1completednot on this map

Vitamin K Injection Treatment for Primary Dysmenorrhea: A Controlled Pilot Study

TypeinterventionalSponsorNational Center for Complementary and Integrative Health (NCCIH)Ran2004 to 2006Enrolled36ConditionsDysmenorrheaArmsAcupuncture point injection of vitamin K
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Vitamin Effects in Primary Dysmenorrhea.Life (Basel, Switzerland) · 2023
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

C WadeRichard & Hinda Rosenthal Center for Complementary and Alternative Medicine Research, College of Physicians and Surgeons, Columbia University, New York, New York, USA Institute of East West Medicine, New York, New York, USA.
L WangObstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai, China.
W J ZhaoObstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai, China.
F CardiniAgenzia Sanitaria e Sociale Regionale dell'Emilia Romagna, (Healthcare and Social Agency of Emilia Romagna Region), Viale Aldo Moro, 21, 40127 Bologna, Italy.
F KronenbergRichard & Hinda Rosenthal Center for Complementary and Alternative Medicine Research, College of Physicians and Surgeons, Columbia University, New York, New York, USA Department of Anesthesiology, Pain and Perioperative Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
S Q GuiObstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai, China.
Z YingDepartment of Statistics, Columbia University, New York, New York, USA.
N Q ZhaoDepartment of Statistics, School of Public Health, Fudan University, Shanghai, Shanghai, China.
M T ChaoRichard & Hinda Rosenthal Center for Complementary and Alternative Medicine Research, College of Physicians and Surgeons, Columbia University, New York, New York, USA Osher Center for Integrative Medicine, University of California at San Francisco, San Francisco, California, USA.
J YuObstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai, China.
Obstetrics and Gynecology Hospital of Fudan University · CNColumbia University · USAgenzia Sanitaria e Sociale Regionale · ITEast-West Management Institute · USFudan University · CNUniversity of California, San Francisco · US

Funding

RESOURCE CENTER FOR AGING RESEARCH IN DIVERSE POPULATIONP30AG015272 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEAH S KARLINER · 1997 to 2026
$19.5M
Group acupuncture for painful diabetic neuropathy among underserved patientsK01AT006545 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAO, MARIA T · 2011 to 2015
$720k
Center for Trad.Chinese Medicine &Women's HealthR21AT001957 · NCCIH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KRONENBERG, FREDI · 2003 to 2004
$271k
NCCIH NIH HHS K01 AT006545NCCIH NIH HHS K01AT006545NCCIH NIH HHS R21 AT001957NCCIH NIH HHS R21-AT01957NIA NIH HHS P30 AG015272
6 · The paper itself

Abstract

objectiveTo determine if injection of vitamin K3 in an acupuncture point is optimal for the treatment of primary dysmenorrhoea, when compared with 2 other injection treatments.

settingA Menstrual Disorder Centre at a public hospital in Shanghai, China.

participantsChinese women aged 14-25 years with severe primary dysmenorrhoea for at least 6 months not relieved by any other treatment were recruited. Exclusion criteria were the use of oral contraceptives, intrauterine devices or anticoagulant drugs, pregnancy, history of abdominal surgery, participation in other therapies for pain and diagnosis of secondary dysmenorrhoea. Eighty patients with primary dysmenorrhoea, as defined on a 4-grade scale, completed the study. Two patients withdrew after randomisation.

interventionsA double-blind, double-dummy, randomised controlled trial compared vitamin K3 acupuncture point injection to saline acupuncture point injection and vitamin K3 deep muscle injection. Patients in each group received 3 injections at a single treatment visit. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the difference in subjective perception of pain as measured by an 11 unit Numeric Rating Scale (NRS). Secondary measurements were Cox Pain Intensity and Duration scales and the consumption of analgesic tablets before and after treatment and during 6 following cycles.

resultsPatients in all 3 groups experienced pain relief from the injection treatments. Differences in NRS measured mean pain scores between the 2 active control groups were less than 1 unit (-0.71, CI -1.37 to -0.05) and not significant, but the differences in average scores between the treatment hypothesised to be optimal and both active control groups (1.11, CI 0.45 to 1.78) and (1.82, CI 1.45 to 2.49) were statistically significant in adjusted mixed-effects models. Menstrual distress and use of analgesics were diminished for 6 months post-treatment.

conclusionsAcupuncture point injection of vitamin K3 relieves menstrual pain rapidly and is a useful treatment in an urban outpatient clinic. TRIAL REGISTRATION NUMBER: NCT00104546; Results.

Indexed as

Acupuncture PointsPain ManagementAcupuncture TherapyAdolescentAdultChinaDouble-Blind MethodDysmenorrheaFemaleHumansInjectionsPainPregnancyVitamin K 3VitaminsYoung AdultVitamin K 3Vitaminsacupuncturedysmenorrheamenstruationpainvitamin k

Identifiers

PMID26733563
PMCPMC4716272
OpenAlexW2230605915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.