ArticleMolecular biology and evolution2016
Adaptive Genetic Robustness of Escherichia coli Metabolic Fluxes.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Congruence between noise and plasticity in protein expression.Scientific reports · 2025Article
- Promoters Constrain Evolution of Expression Levels of Essential Genes in Escherichia coli.Molecular biology and evolution · 2024Article
- Plant biochemical genetics in the multiomics era.Journal of experimental botany · 2023Review
- Curating COBRA Models of Microbial Metabolism.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The impact of cell structure, metabolism and group behavior for the survival of bacteria under stress conditions.Archives of microbiology · 2021Review
- Environmental flexibility does not explain metabolic robustness.NPJ systems biology and applications · 2020Article
- Genetic buffering and potentiation in metabolism.PLoS computational biology · 2020Article
- Opportunities at the Interface of Network Science and Metabolic Modeling.Frontiers in bioengineering and biotechnology · 2020Review
- Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen.Nature communications · 2018Article
- Evolutionary adaptations to new environments generally reverse plastic phenotypic changes.Nature communications · 2018Article
- Network Architecture and Mutational Sensitivity of theFrontiers in molecular biosciences · 2018Article
- Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence FromFrontiers in genetics · 2018Article
- Why Phenotype Robustness Promotes Phenotype Evolvability.Genome biology and evolution · 2017Article
- Canalization of Tomato Fruit Metabolism.The Plant cell · 2017Article
- Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.RNA (New York, N.Y.) · 2016Article
- Nitric Oxide Overproduction in TomatoFrontiers in plant science · 2016Article
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2 authors.
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Abstract
Genetic robustness refers to phenotypic invariance in the face of mutation and is a common characteristic of life, but its evolutionary origin is highly controversial. Genetic robustness could be an intrinsic property of biological systems, a result of direct natural selection, or a byproduct of selection for environmental robustness. To differentiate among these hypotheses, we analyze the metabolic network of Escherichia coli and comparable functional random networks. Treating the flux of each reaction as a trait and computationally predicting trait values upon mutations or environmental shifts, we discover that 1) genetic robustness is greater for the actual network than the random networks, 2) the genetic robustness of a trait increases with trait importance and this correlation is stronger in the actual network than in the random networks, and 3) the above result holds even after the control of environmental robustness. These findings demonstrate an adaptive origin of genetic robustness, consistent with the theoretical prediction that, under certain conditions, direct selection is sufficiently powerful to promote genetic robustness in cellular organisms.
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