Evidence map›Paper›PMID 26733400›Full record

ArticleEpidemiology and infection2016

Herpes simplex virus encephalitis in Peru: a multicentre prospective study.

S M Montano, N Mori, C A Nelson, T G N Ton, V Celis, E Ticona, M Sihuincha, D H Tilley, T Kochel, J R Zunt and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Global Landscape of Encephalitis: Key Priorities to Reduce Future Disease Burden.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

S M MontanoUS Naval Medical Research Unit-6,Callao,Peru.
N MoriFogarty International Center,National Institutes of Health,Bethesda,MD,USA.
C A NelsonFogarty International Center,National Institutes of Health,Bethesda,MD,USA.
T G N TonDepartment of Neurology,School of Medicine,University of Washington,Seattle,WA,USA.
V CelisHospital Belen,Trujillo,Peru.
E TiconaHospital Dos de Mayo,Lima,Peru.
M SihuinchaHospital Cesar Garayar García,Loreto,Peru.
D H TilleyUS Naval Medical Research Unit-6,Callao,Peru.
T KochelUS Naval Medical Research Unit-6,Callao,Peru.
J R ZuntDepartment of Neurology,School of Medicine,University of Washington,Seattle,WA,USA.
Meningoencephalitis Working Group

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Retrovial Infections of the Nervous System in PeruR01NS055627 · NINDS · UNIVERSITY OF WASHINGTON · PI ZUNT, JOSEPH RAYMOND · 2006 to 2010
$3.0M
FIC NIH HHS R24 TW007988NINDS NIH HHS R01 NS055627
6 · The paper itself

Abstract

Herpes simplex virus (HSV) is one of the most commonly identified infectious aetiologies of encephalitis in North America and Europe. The epidemiology of encephalitis beyond these regions, however, is poorly defined. During 2009-2012 we enrolled 313 patients in a multicentre prospective study of encephalitis in Peru, 45 (14·4%) of whom had confirmed HSV infection. Of 38 patients with known HSV type, 84% had HSV-1 and 16% had HSV-2. Patients with HSV infection were significantly more likely to present in the summer months (44·4% vs. 20·0%, P = 0·003) and have nausea (60·0% vs. 39·8%, P = 0·01) and rash (15·6% vs. 5·3%, P = 0·01) compared to patients without HSV infection. These findings highlight differences in the epidemiology and clinical presentation of HSV encephalitis outside of the Northern Hemisphere that warrant further investigation. Furthermore, there is an urgent need for improved HSV diagnostic capacity and availability of intravenous acyclovir in Peru.

Indexed as

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolEncephalitis, Herpes SimplexFemaleHumansInfantMaleMiddle AgedPeruProspective StudiesSeasonsSimplexvirusCentral nervous system infectionsencephalitisepidemiologyherpes simplex virusvirology

Identifiers

PMID26733400
PMCPMC9150612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.