ArticleCurrent molecular medicine2016
DREADD in parvalbumin interneurons of the dentate gyrus modulates anxiety, social interaction and memory extinction.
Article in Current molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 119 citations in OpenAlex.
- Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice.Neuron · 2026Article
- Molecular pathways underlying amyloid precursor protein-mediated regulation of adult-born neurons.Neural regeneration research · 2026Article
- Stress-induced reduction of sodium leak currents causes social deficits by impairing dorsal dentate gyrus-medial septum glutamatergic projection.Molecular psychiatry · 2025Article
- Environmental exposure to common pesticide induces synaptic deficit and social memory impairment driven by neurodevelopmental vulnerability of hippocampal parvalbumin interneurons.Journal of hazardous materials · 2025Article
- Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation.Cell reports · 2025Article
- Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors.Neurobiology of disease · 2025Article
- Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLActa pharmacologica Sinica · 2024Article
- Hippocampus: Molecular, Cellular, and Circuit Features in Anxiety.Neuroscience bulletin · 2023Review
- Prepubertal ovariectomy confers resilience to stress-induced anxiety in adult female mice.Psychoneuroendocrinology · 2023Article
- Differential expression of GABAFrontiers in cellular neuroscience · 2023Article
- Sucrose Consumption during Late Adolescence Impairs Adult Neurogenesis of the Ventral Dentate Gyrus without Inducing an Anxiety-like Behavior.International journal of molecular sciences · 2022Article
- The antidepressant effect of nucleus accumbens deep brain stimulation is mediated by parvalbumin-positive interneurons in the dorsal dentate gyrus.Neurobiology of stress · 2022Article
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Choosing memory retrieval strategies: A critical role for inhibition in the dentate gyrus.Neurobiology of stress · 2022Article
- Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice.BMC biology · 2022Article
- Altered synaptic plasticity of the longitudinal dentate gyrus network in noise-induced anxiety.iScience · 2022Article
- Anxiety and hippocampal neuronal activity: Relationship and potential mechanisms.Cognitive, affective & behavioral neuroscience · 2022Review
- CTCF in parvalbumin-expressing neurons regulates motor, anxiety and social behavior and neuronal identity.Molecular brain · 2022Article
- Chronic Behavioral Manipulation via Orally Delivered Chemogenetic Actuator in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Interneuron function and cognitive behavior are preserved upon postnatal removal of Lhx6.Scientific reports · 2022Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parvalbumin (PV)-positive interneurons in the hippocampus play a critical role in animal memory, such as spatial working memory. However, how PV-positive interneurons in the subregions of the hippocampus affect animal behaviors remains poorly defined. Here, we achieved specific and reversible activation of PV-positive interneurons using designer receptors exclusively activated by designer drugs (DREADD) technology. Inducible DREADD expression was demonstrated in vitro in cultured neurons, in which co-transfection of the hM3D-Gq-mCherry vector with a Cre plasmid resulted in a cellular response to hM3Dq ligand clozapine-N-oxide (CNO) stimulation. In addition, the dentate gyrus (DG) of PV-Cre mice received bilateral injection of control lentivirus or lentivirus expressing double floxed hM3D-Gq-mCherry. Selective activation of PV-positive interneurons in the DG did not affect locomotor activity or depression-related behavior in mice. Interestingly, stimulation of PV-positive interneurons induced an anxiolytic effect. Activation of PVpositive interneurons appears to impair social interaction to novelty, but has no effect on social motivation. However, this defect is likely due to the anxiolytic effect as the exploratory behavior of mice expressing hM3DGq is significantly increased. Mice expressing hM3D-Gq did not affect novel object recognition. Activation of PV-positive interneurons in the DG maintains intact cued and contextual fear memory but facilitates fear extinction. Collectively, our results demonstrated that proper control of PV interneurons activity in the DG is critical for regulation of the anxiety, social interaction and fear extinction. These results improve our fundamental understanding of the physiological role of PV-positive interneurons in the hippocampus.
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