ArticleFrontiers in microbiology2015
Faustovirus-Like Asfarvirus in Hematophagous Biting Midges and Their Vertebrate Hosts.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- The Role of Hematophagous Arthropods, Other than Mosquitoes and Ticks, in Arbovirus Transmission.Viruses · 2025Review
- 20 years of research on giant viruses.Npj viruses · 2025Review
- Discovery of Novel Viruses inViruses · 2024Article
- Asfarviruses and Closely Related Giant Viruses.Viruses · 2023Review
- Meta-Viromic Sequencing Reveals Virome Characteristics of Mosquitoes andMicrobiology spectrum · 2023Article
- Dissecting the Species-Specific Virome inFrontiers in microbiology · 2022Article
- Diversity of Giant Viruses InfectingFrontiers in microbiology · 2022Review
- Virome Diversity among Mosquito Populations in a Sub-Urban Region of Marseille, France.Viruses · 2021Article
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- High-throughput isolation of giant viruses using high-content screening.Communications biology · 2019Article
- Putative Promoter Motif Analyses Reinforce the Evolutionary Relationships Among Faustoviruses, Kaumoebavirus, and Asfarvirus.Frontiers in microbiology · 2018Article
- Faustovirus E12 Transcriptome Analysis Reveals Complex Splicing in Capsid Gene.Frontiers in microbiology · 2018Article
- A Large Open Pangenome and a Small Core Genome for Giant Pandoraviruses.Frontiers in microbiology · 2018Article
- Viral Metagenomics on Blood-Feeding Arthropods as a Tool for Human Disease Surveillance.International journal of molecular sciences · 2016Review
- Bunyaviruses are common in male and female Ixodes scapularis ticks in central Pennsylvania.PeerJ · 2016Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Faustovirus, a new Asfarviridae-related giant virus, was recently isolated in Vermamoeba vermiformis, a protist found in sewage water in various geographical locations and occasionally reported in human eye infection cases. As part of a global metagenomic analysis of viral communities existing in biting midges, we report here for the first time the identification and isolation of a Faustovirus-like virus in hematophagous arthropods and its detection in their animal hosts. The DNA virome analysis of three pools of Culicoides sp., engorged female Culicoides imicola and non-engorged male/female C. imicola biting midges collected in Senegal, revealed the presence of amoeba-infecting giant viruses and, among them, a majority of sequences related to Faustovirus. Phylogenetic analyses conducted on several structural genes of Faustovirus confirmed the clustering of the arthropod-borne Faustovirus with sewage-borne Faustoviruses, with a distinct geographical clustering of Senegalese Faustovirus strains. Transmission electron microscopy identified viral particles with morphologies and diameters which were compatible with Faustovirus. The presence of infectious arthropod-borne Faustovirus was finally confirmed by successful isolation on V. vermiformis amoeba. Global proteomic analysis of biting midges identified that arthropods' blood meal originating from cattle, rodents and humans. Further screening of cattle sera and rodent tissue resulted in prevalence of Faustovirus being estimated at 38% in rodents and 14% in cattle, suggesting a possible origin of Faustovirus presence in arthropods via the ingestion of contaminated blood meal. Viral loads were the highest in rodents' urine and kidney samples, suggesting a possible excretion of viral particles into the environment. Faustovirus DNA polymerase-related sequences were also detected in more than 9 and 11% of febrile patients and healthy Senegalese human sera, respectively. Our study thus, highlights the need to investigate the role of arthropods, wildlife, and domestic animals in the lifecycle of amoeba-infecting giant viruses and, in particular, the environmental cycle of Faustovirus.
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