Evidence map›Paper›PMID 26733044›Full record

ReviewSeminars in immunopathology2016

A genetic perspective on granulomatous diseases with an emphasis on mycobacterial infections.

Un-In Wu, Steven M Holland

Abstract readReview
In one paragraph

Review in Seminars in immunopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Impact of Aging and HIV Infection on the Function of the C-Type Lectin Receptor MINCLE in Monocytes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Article
  6. Review
  7. Immunopathology of mycobacterial diseases.Seminars in immunopathology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Un-In WuDivision of Infectious Diseases, National Taiwan University Hospital, Taipei, Taiwan. uninwu@gmail.com.
Steven M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, CRC B3-4141 MSC 1684, Bethesda, MD, 20892-1684, USA. smh@nih.gov.

Funding

Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
International Research in ThailandZIAAI001069 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$4.3M
Rituximab for Anticytokine Autoantibody-Associated SyndromesZIAAI001182 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2013 to 2025
$3.0M
TRANSGENIC ANIMAL MODELS OF HUMAN IMMUNE DEFECTSZ01AI000646 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HOLLAND, STEVEN M · 1992 to 2008
$2.4M
Intramural NIH HHS Z01 AI000646
6 · The paper itself

Abstract

Identification of the genetic factors predisposing to mycobacterial infections has been a subject of intense research activities. Current knowledge of the genetic and immunological basis of susceptibility to mycobacteria largely comes from natural human and experimental models of Bacille Calmette Guérin (BCG) and nontuberculous mycobacterial infections. These observations support the central role of the IL-12/IFN-γ pathway in controlling mycobacterial infection. In this review, we discuss the knowledge that associates both simple and complex inheritance with susceptibility to mycobacterial diseases. We place a special emphasis on monogenic disorders, since these clearly pinpoint pathways and can adduce mechanism. We also describe the clinical, immunological, and pathological features that may steer clinical investigation in the appropriate directions.

Indexed as

Genetic Predisposition to DiseaseHost-Pathogen InteractionsAnimalsGenetic Association StudiesGenetic Diseases, InbornGranulomaHumansImmune SystemInterferon-gammaInterleukin-12MycobacteriumMycobacterium InfectionsRisk FactorsSequence DeletionSignal TransductionInterferon-gammaInterleukin-12IFN-γIL-12MycobacteriaNontuberculousTuberculosis

Identifiers

PMID26733044
PMCPMC4779418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.