Evidence map›Paper›PMID 26733021›Full record

ArticleNature communications2016

Human pancreatic beta-like cells converted from fibroblasts.

Saiyong Zhu, Holger A Russ, Xiaojing Wang, Mingliang Zhang, Tianhua Ma, Tao Xu, Shibing Tang, Matthias Hebrok, Sheng Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saiyong ZhuGladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.
Holger A RussDiabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
Xiaojing WangGladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.
Mingliang ZhangGladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.
Tianhua MaGladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.
Tao XuGladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.
Shibing TangGladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.ORCID http://orcid.org/0000-0001-8592-3477
Matthias HebrokDiabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
Sheng DingGladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94158, USA.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
"Expanding beta-cell mass"U01DK089541 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S, HEBROK, MATTHIAS · 2010 to 2014
$5.1M
Regulation of beta cell identity and dedifferentiationR01DK105831 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HEBROK, MATTHIAS · 2015 to 2022
$2.9M
NIDDK NIH HHS DK089541NIDDK NIH HHS DK105831NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK63720NIDDK NIH HHS R01 DK105831NIDDK NIH HHS U01 DK089541
6 · The paper itself

Abstract

Pancreatic beta cells are of great interest for biomedical research and regenerative medicine. Here we show the conversion of human fibroblasts towards an endodermal cell fate by employing non-integrative episomal reprogramming factors in combination with specific growth factors and chemical compounds. On initial culture, converted definitive endodermal progenitor cells (cDE cells) are specified into posterior foregut-like progenitor cells (cPF cells). The cPF cells and their derivatives, pancreatic endodermal progenitor cells (cPE cells), can be greatly expanded. A screening approach identified chemical compounds that promote the differentiation and maturation of cPE cells into functional pancreatic beta-like cells (cPB cells) in vitro. Transplanted cPB cells exhibit glucose-stimulated insulin secretion in vivo and protect mice from chemically induced diabetes. In summary, our study has important implications for future strategies aimed at generating high numbers of functional beta cells, which may help restoring normoglycemia in patients suffering from diabetes.

Indexed as

AnimalsCell Culture TechniquesCell DifferentiationDiabetes Mellitus, ExperimentalFibroblastsGlucoseHumansInsulinInsulin-Secreting CellsInsulin SecretionMiceStem CellsGlucoseInsulin

Identifiers

PMID26733021
PMCPMC4729817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.