ArticleNature communications2016
Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Atypical E-cadherin attachments mediate melanoblast migration through confined epithelial spaces.The Journal of cell biology · 2026Article
- Structural and epistatic regulatory variants cause hallmark white spotting in cattle.Science advances · 2025Article
- Inference and prediction for stochastic models of biological populations undergoing migration and proliferation.Journal of the Royal Society, Interface · 2025Review
- Interphase cell morphology defines the mode, symmetry, and outcome of mitosis.Science (New York, N.Y.) · 2025Article
- How the tulip breaking virus creates striped tulips.Communications biology · 2025Article
- Discrete and continuous mathematical models of sharp-fronted collective cell migration and invasion.Royal Society open science · 2024Article
- A biased random walk approach for modeling the collective chemotaxis of neural crest cells.Journal of mathematical biology · 2024Article
- Fluctuations in tissue growth portray homeostasis as a critical state and long-time non-Markovian cell proliferation as Markovian.Royal Society open science · 2023Article
- Biology of melanocytes in mammals.Frontiers in cell and developmental biology · 2023Review
- Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage.Pigment cell & melanoma research · 2023Article
- Synchronized oscillations in growing cell populations are explained by demographic noise.Biophysical journal · 2021Article
- Incorporating domain growth into hybrid methods for reaction-diffusion systems.Journal of the Royal Society, Interface · 2021Article
- The blending region hybrid framework for the simulation of stochastic reaction-diffusion processes.Journal of the Royal Society, Interface · 2020Article
- Modelling collective cell migration: neural crest as a model paradigm.Journal of mathematical biology · 2020Article
- Modelling chase-and-run migration in heterogeneous populations.Journal of mathematical biology · 2020Article
- Modeling and analysis of melanoblast motion.Journal of mathematical biology · 2019Article
- The auxiliary region method: a hybrid method for coupling PDE- and Brownian-based dynamics for reaction-diffusion systems.Royal Society open science · 2018Article
- Simulation of melanoblast displacements reveals new features of developmental migration.Development (Cambridge, England) · 2018Article
- Spatially extended hybrid methods: a review.Journal of the Royal Society, Interface · 2018Review
- The patterns of birthmarks suggest a novel population of melanocyte precursors arising around the time of gastrulation.Pigment cell & melanoma research · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of the directed dorsoventral migration of melanoblasts (the embryonic precursors of melanocytes) as they colonize the developing skin. Depigmented 'belly spots' in mice with mutations in the receptor tyrosine kinase Kit are thought to represent a failure of this colonization, either due to impaired migration or proliferation. Tracing of single melanoblast clones, however, has revealed a diffuse distribution with high levels of axial mixing--hard to reconcile with directed migration. Here we construct an agent-based stochastic model calibrated by experimental measurements to investigate the formation of diffuse clones, chimeric stripes and belly spots. Our observations indicate that melanoblast colonization likely proceeds through a process of undirected migration, proliferation and tissue expansion, and that reduced proliferation is the cause of the belly spots in Kit mutants.
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Registered trials
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