ArticleNature communications2016
Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Active deformation in the basal organ of Corti in gerbil.Biophysical journal · 2026Article
- Study of organ of Corti motion in the guinea pig base including differential analysis of internal motion.Hearing research · 2025Article
- Suppression of Low-Frequency Tones in the Organ of Corti Vibrations of the Basal Turn in the Mongolian Gerbil Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Advective mass transport along the cochlear coil.AIP conference proceedings · 2024Article
- The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Prestin's fast motor kinetics is essential for mammalian cochlear amplification.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea.Scientific reports · 2022Article
- Outer hair cell driven reticular lamina mechanical distortion in living cochleae.Hearing research · 2022Review
- Salicylate-induced changes in organ of Corti vibrations.Hearing research · 2022Article
- An outer hair cell-powered global hydromechanical mechanism for cochlear amplification.Hearing research · 2022Article
- Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The origin of mechanical harmonic distortion within the organ of Corti in living gerbil cochleae.Communications biology · 2021Article
- Cochlear mechanics: new insights from vibrometry and Optical Coherence Tomography.Current opinion in physiology · 2020Article
- The cochlear ear horn: geometric origin of tonotopic variations in auditory signal processing.Scientific reports · 2020Article
- Characterisation of the static offset in the travelling wave in the cochlear basal turn.Pflugers Archiv : European journal of physiology · 2020Article
- Article
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Voltage readout from a piezoelectric intracochlear acoustic transducer implanted in a living guinea pig.Scientific reports · 2019Article
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Authors and funding
3 authors.
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Abstract
It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This 'reverse transduction' force production has never been demonstrated experimentally, however, in the living ear. Here by directly measuring microstructure vibrations inside the cochlear partition using a custom-built interferometer, we demonstrate that electrical stimulation can evoke both fast broadband and slow sharply tuned responses of the reticular lamina, but only a slow tuned response of the basilar membrane. Our results indicate that outer hair cells can generate sufficient force to drive the reticular lamina over all audible frequencies in living cochleae. Contrary to expectations, the cellular force causes a travelling wave rather than an immediate local vibration of the basilar membrane; this travelling wave vibrates in phase with the reticular lamina at the best frequency, and results in maximal vibration at the apical ends of outer hair cells.
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