ArticleAge (Dordrecht, Netherlands)2016
G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old.
Article in Age (Dordrecht, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Nitride oxide synthase 3 and klotho gene polymorphisms in the pathogenesis of chronic kidney disease and age-related cognitive impairment: a systematic review and meta-analysis.F1000Research · 2020Pooled it
- Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study.BMC geriatrics · 2018Trial
- The inflection point: α-Klotho levels and the risk of all-cause mortality.Frontiers in endocrinology · 2025Article
- Sex differences in the association between Life's Essential 8 and serum anti-aging Klotho protein levels: a cross-sectional analysis in middle-aged to older adults.Frontiers in aging · 2025Article
- Role of Klotho Protein in Neuropsychiatric Disorders: A Narrative Review.Indian journal of clinical biochemistry : IJCB · 2023Review
- Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction.Neuronal signaling · 2021Review
- Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies.Molecular neurobiology · 2021Review
- Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders.Frontiers in psychiatry · 2021Article
- Klotho and the Treatment of Human Malignancies.Cancers · 2020Review
- Klotho and vitamin D in multiple sclerosis: an Italian study.Archives of medical science : AMS · 2020Article
- The predictive value of Klotho polymorphism, in addition to classical markers of CKD-MBD, for left ventricular hypertrophy in haemodialysis patients.International urology and nephrology · 2019Article
- Klotho at the Edge of Alzheimer's Disease and Senile Depression.Molecular neurobiology · 2019Review
- Klotho, the Key to Healthy Brain Aging?Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Klotho G-395A gene polymorphism: impact on progression of end-stage renal disease and development of cardiovascular complications in children on dialysis.Pediatric nephrology (Berlin, Germany) · 2018Article
- G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to examine the possible association between G-395A polymorphism in the promoter region of the KLOTHO gene and cognitive impairment among Chinese nonagenarians and centenarians. This study is a secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study. Community-dwelling Chinese people aged 90 years or older were included. G-395A (rs1207568) genotyping in the promoter region of the KLOTHO gene was performed using the TaqMan allelic discrimination assay. Cognitive function was assessed with the mini-mental status examination (MMSE). A total of 706 participants (68.0 % female; mean age 93.5 ± 3.6 years) were included. The KLOTHO G-395A polymorphism genotype frequencies for the whole sample were 2.0 % AA, 30.3 % GA, and 67.7 % GG. The GG genotype frequencies for the cognitive impairment and control groups were 70.2 and 62.7 %, respectively. Cognitive impairment prevalence was significantly lower in the GA+AA group than in the GG genotype group (61.4 vs. 69.0 %, p = 0.044). GA+AA genotype subjects had a significantly lower risk of cognitive impairment (odds ratio 0.66; 95 % confidence interval 0.44 to 0.98) than GG genotype individuals after adjusting for age, gender, and other relevant risk factors. KLOTHO G-395A polymorphism associates with reduced cognitive impairment in a sample of Chinese nonagenarians and centenarians.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.