ArticleScientific reports2016
The recent ancestry of Middle East respiratory syndrome coronavirus in Korea has been shaped by recombination.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Evolutionary Insight into Fatal Human Coronaviruses (hCoVs) with a Focus on Circulating SARS-CoV-2 Variants Under Monitoring (VUMs).Biomedicines · 2025Review
- Vaccines Targeting Numerous Coronavirus Antigens, Ensuring Broader Global Population Coverage: Multi-epitope and Multi-patch Vaccines.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Recombination in Positive-Strand RNA Viruses.Frontiers in microbiology · 2022Review
- Article
- A genetic barcode of SARS-CoV-2 for monitoring global distribution of different clades during the COVID-19 pandemic.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- Article
- An Overview of the Genetic Variations of the SARS-CoV-2 Genomes Isolated in Southeast Asian Countries.Journal of microbiology and biotechnology · 2020Review
- Article
- Animal models for the risk assessment of viral pandemic potential.Laboratory animal research · 2020Review
- Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences.Journal of veterinary science · 2019Article
- Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea.The Korean journal of internal medicine · 2018Review
- Review
- Pathogen genomic surveillance elucidates the origins, transmission and evolution of emerging viral agents in China.Science China. Life sciences · 2017Review
- Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing, Abu Dhabi, United Arab Emirates.Emerging microbes & infections · 2017Article
- The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea, 2015.BMC infectious diseases · 2017Article
- The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages.Emerging microbes & infections · 2017Article
- Molecular Evolution of Human Coronavirus Genomes.Trends in microbiology · 2017Review
- The Middle East Respiratory Syndrome Coronavirus - A Continuing Risk to Global Health Security.Advances in experimental medicine and biology · 2017Article
- Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus.Cold Spring Harbor molecular case studies · 2016Article
- Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
24 authors at 10 institutions in 3 countries.
Funding
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe cases of human respiratory disease. Since 2012, the victims have mainly come from the Middle East countries or sporadically from some other geographical regions seeded by the travelers who visited the Middle East. Such an introduction through travelling led to the emergence of a MERS-CoV outbreak in Korea in May 2015, which caused more than 140 confirmed human cases in less than a month. Using 70 complete genome sequences of MERS-CoV isolates, including the most recent sequences for the Korean and Chinese isolates, we reconstructed the phylogenetic relationships of the complete genome and the individual protein coding regions. The Korean MERS-CoV strain clustered in the previously established Hafr-Al-Batin-1_2013 clade together with two Saudi Arabian and one Chinese strain sampled in 2015. Although these four strains remained monophyletic in the entire protein-coding region, this clade showed different phylogenetic relationships across the genome, indicating a shared unique recombination pattern that is different from previously reported putative recombination strains. Our findings suggest that the recent ancestor of the Korean and its related MERS-CoV strains is characterized by unique mosaic genome pattern that is different from other putative recombinants.
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