ArticleMolecular neurobiology2017
GWAS-Linked Loci and Neuroimaging Measures in Alzheimer's Disease.
Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- DDT exposure induces microglial activation and disease-associated microglial signatures: Relevance to mechanisms of Alzheimer's disease.Neurotoxicology · 2025Article
- MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer's disease model.Molecular neurodegeneration · 2025Article
- The Association between the rs6656401 Locus of the CR1 Gene and Structural Alterations of Brain Effects in Han Chinese Patients with Alzheimer's Disease.Current Alzheimer research · 2025Article
- A global view of the genetic basis of Alzheimer disease.Nature reviews. Neurology · 2023Review
- Revealing the correlations between brain cortical characteristics and susceptibility genes for Alzheimer disease: a cross-sectional study.Quantitative imaging in medicine and surgery · 2023Article
- The relationship of early- and late-onset Alzheimer's disease genes with COVID-19.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- The impact of Alzheimer's disease susceptibility loci on lateral ventricular surface morphology in older adults.Brain structure & function · 2022Article
- Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models.Neurobiology of disease · 2021Review
- Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.Alzheimer's research & therapy · 2021Article
- Polygenic Hazard Score Associated Multimodal Brain Networks Along the Alzheimer's Disease Continuum.Frontiers in aging neuroscience · 2021Article
- Integrating Transcriptomics, Genomics, and Imaging in Alzheimer's Disease: A Federated Model.Frontiers in radiology · 2021Article
- Association of MS4A6A, CD33, and TREM2 gene polymorphisms with the late-onset Alzheimer's disease.BioImpacts : BI · 2019Article
- A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer's Disease.Biological psychiatry · 2018Article
- [Verification of a sporadic Alzheimer disease model in SORL1 gene knockout mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- MS4A6A genotypes are associated with the atrophy rates of Alzheimer's disease related brain structures.Oncotarget · 2016Article
- Toward precision medicine in neurological diseases.Annals of translational medicine · 2016Review
- The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
Recently, 19 susceptibility loci for Alzheimer's disease (AD) had been identified through AD genome-wide association studies (GWAS) meta-analysis. However, how they influence the pathogenesis of AD still remains largely unknown. We studied those loci with six MRI measures, abnormal glucose metabolism, and β-amyloid (Aβ) deposition on neuroimaging in a large cohort from Alzheimer's Disease Neuroimaging Initiative (ADNI) database in order to provide clues of the mechanisms through which these genetic variants might be acting. As a result, single nucleotide polymorphisms (SNPs) at rs983392 within MS4A6A and rs11218343 within SOLR1 were both associated with the percentage of increase in the volume of left inferior temporal regions in the follow-up study. Meanwhile, rs11218343 at SORL1 and rs6733839 at BIN1 was associated with rate of volume change of left parahippocampal and right inferior parietal, respectively. Moreover, rs6656401 at CR1 and rs983392 at MS4A6A were both associated with smaller volume of right middle temporal at baseline. However, in addition to the APOE locus, we did not detect any influence on glucose metabolism and Aβ deposition. APOE ε4 allele was associated with almost all measures. Altogether, five loci (rs6656401 at CR1, rs983392within MS4A6A, rs11218343 at SORL1, rs6733839 at BIN1, and APOE ε4) have been detected to be associated with one or a few established AD-related neuroimaging measures.
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