Evidence map›Paper›PMID 26732571›Full record

ArticleStroke2016

Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats.

Zongduo Guo, Qin Hu, Liang Xu, Zhen-Ni Guo, Yibo Ou, Yue He, Cheng Yin, Xiaochuan Sun, Jiping Tang, John H Zhang

Expression of concernAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. The polyunsaturated fatty acid and oxylipin plasma signature of aneurysmal subarachnoid haemorrhage, case-control study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
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  10. A signaling network map of Lipoxin (LXA4): an anti-inflammatory molecule.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  11. Article
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  19. Review
  20. Lipoxin alleviates oxidative stress: a state-of-the-art review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zongduo GuoFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
Qin HuFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
Liang XuFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
Zhen-Ni GuoFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
Yibo OuFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
Yue HeFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
Cheng YinFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
Xiaochuan SunFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
Jiping TangFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.).
John H ZhangFrom the Departments of Anesthesiology and Physiology, Loma Linda University School of Medicine, CA (Z.G., Q.H., L.X., Z.-N.G., Y.O., Y.H., C.Y., J.T., J.H.Z.); and Department of Neurosurgery, the 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China (Z.G., X.S.). johnzhang3910@yahoo.com.
Dalian Medical University · CN

Funding

Vascular Biology Core FacilityP01NS082184 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2014 to 2018
$6.1M
Neurovascular Protection for Early Brain Injury after SAHR01NS081740 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2013 to 2017
$1.6M
NINDS NIH HHS NS081740NINDS NIH HHS NS082184NINDS NIH HHS P01 NS082184NINDS NIH HHS R01 NS081740
6 · The paper itself

Abstract

background and purposeLipoxin A4 (LXA4) has been reported to reduce inflammation in several neurological injury models. We studied the effects of LXA4 on neuroinflammation after subarachnoid hemorrhage (SAH) in a rat model.

methodsTwo hundred and thirty-eight Sprague-Dawley male rats, weight 280-320 g, were used. Exogenous LXA4 (0.3 and 1.0 nmol) were injected intracerebroventricularly at 1.5 hours after SAH. Neurological scores, brain water content, and blood-brain barrier were evaluated at 24 hours after SAH; Morris water maze and T-maze tests were examined at 21 days after SAH. The expression of endogenous LXA4 and its receptor formyl peptide receptor 2 (FPR2), as well as p38, interleukin-1β, and interleukin-6 were studied either by ELISA or by Western blots. Neutrophil infiltration was observed by myeloperoxidase staining. FPR2 siRNA was used to knock down LXA4 receptor.

resultsThe expression of endogenous LXA4 decreased, and the expression of FPR2 increased after SAH. Exogenous LXA4 decreased brain water content, reduced Evans blue extravasation, and improved neurological functions and improved the learning and memory ability after SAH. LXA4 reduced neutrophil infiltration and phosphorylation of p38, interleukin-1β, and interleukin-6. These effects of LXA4 were abolished by FPR2 siRNA.

conclusionsExogenous LXA4 inhibited inflammation by activating FPR2 and inhibiting p38 after SAH. LXA4 may serve as an alternative treatment to relieve early brain injury after SAH.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalBehavior, AnimalBlood-Brain BarrierBlotting, WesternBrain EdemaEnzyme-Linked Immunosorbent AssayGene Knockdown TechniquesInflammationInjections, IntraventricularInterleukin-1betaInterleukin-6LipoxinsMaleMemoryNeuropsychological TestsAnti-Inflammatory Agents, Non-SteroidalIL1B protein, ratInterleukin-1betaInterleukin-6lipoxin A4lipoxin A(4) receptor, ratLipoxinsp38 Mitogen-Activated Protein KinasesReceptors, Lipoxinblood–brain barrierformyl peptide receptor 2inflammationlipoxin A4subarachnoid hemorrhage

Identifiers

PMID26732571
PMCPMC4729632
OpenAlexW2224723723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.