ArticleScientific reports2016
Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Advances and challenges in intravital imaging of craniofacial and dental progenitor cells.Genesis (New York, N.Y. : 2000) · 2022Review
- A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.The Journal of clinical investigation · 2022Article
- Integrin CD11b provides a new marker of pre-germinal center IgA+ B cells in murine Peyer's patches.International immunology · 2022Article
- Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum.Gut · 2022Article
- Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice.PloS one · 2022Article
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- Actually Seeing What Is Going on - Intravital Microscopy in Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021Review
- Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide.Frontiers in cellular neuroscience · 2021Article
- Article
- Visualization of mechanical stress-mediated CaBioscience of microbiota, food and health · 2020Article
- Propolis induces CaBioscience of microbiota, food and health · 2019Article
- Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility.iScience · 2018Article
- Intravital Two-photon Imaging of CaScientific reports · 2018Article
- Article
- In vivo multiphoton imaging of immune cell dynamics.Pflugers Archiv : European journal of physiology · 2016Review
- Visualization of Probiotic-Mediated CaFrontiers in immunology · 2016Article
- Recognition of acrolein-specific epitopes by B cell receptors triggers an innate immune response.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium ion (Ca(2+)) signaling is a typical phenomenon mediated through immune receptors, such as the B-cell antigen receptor (BCR), and it is important for their biological activities. To analyze the signaling of immune receptors together with their in vivo dynamics, we generated stable transgenic mice with the Föster/fluorescence resonance energy transfer (FRET)-based Ca(2+) indicator yellow cameleon 3.60 (YC3.60), based on the Cre/loxP system (YC3.60(flox)). We successfully obtained mice with specific YC3.60 expression in immune or nerve cells as well as mice with ubiquitous expression of this indicator. We established five-dimensional (5D) (x, y, z, time, and Ca(2+)) intravital imaging of lymphoid tissues, including the bone marrow. Furthermore, in autoimmune-prone models, the CD22(-/-) and C57BL/6- lymphoproliferation (lpr)/lpr mouse, Ca(2+) fluxes were augmented, although they did not induce autoimmune disease. Intravital imaging of Ca(2+) signals in lymphocytes may improve assessment of the risk of autoimmune diseases in model animals.
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