SynthesisHuman molecular genetics2016
Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.Nature communications · 2024Pooled it
- Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.Nature communications · 2023Pooled it
- Mapping the human genetic architecture of COVID-19.Nature · 2021Pooled it
- Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.Molecular carcinogenesis · 2018Pooled it
- Lung cancer in never-smoking females: epidemiology, risk factors and screening.Frontiers in public health · 2026Review
- Formal Statistical Replication Analysis in Lung Cancer Genome-Wide Association Studies.medRxiv : the preprint server for health sciences · 2025Article
- Genome-wide association study of long COVID.Nature genetics · 2025Article
- Prediction and assessment of deleterious and disease causing nonsynonymous single nucleotide polymorphisms (nsSNPs) in humanHeliyon · 2024Article
- Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity.British journal of cancer · 2024Article
- Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Lung cancer in patients who have never smoked - an emerging disease.Nature reviews. Clinical oncology · 2024Review
- Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan.JAMA network open · 2023Article
- Lung cancer in never smokers (LCINS): development of a UK national research strategy.BJC reports · 2023Review
- Nomograms Using CT Morphological Features and Clinical Characteristics to Identify COPD in Patients with Lung Cancer: A Multicenter Study.International journal of chronic obstructive pulmonary disease · 2023Article
- Etiology of lung cancer: Evidence from epidemiologic studies.Journal of the National Cancer Center · 2022Review
- Functional studies of lung cancer GWAS beyond association.Human molecular genetics · 2022Review
- SNP rs9387478 at ROS1-DCBLD1 Locus is Significantly Associated with Lung Cancer Risk and Poor Survival in Indian Population.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- The human genetic epidemiology of COVID-19.Nature reviews. Genetics · 2022Review
- Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk.Human molecular genetics · 2022Article
- Deep-LC: A Novel Deep Learning Method of Identifying Non-Small Cell Lung Cancer-Related Genes.Frontiers in oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
150 authors.
Zhaoming WangCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Gaithersburg, MD, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA, wangzha@mail.nih.gov.
Wei Jie SeowDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Kouya ShiraishiDivision of Genome Biology, National Cancer Center Hospital, Tokyo, Japan.
Chao A HsiungInstitute of Population Health Sciences.
Keitaro MatsuoDivision of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
Jie LiuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Kexin ChenDepartment of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Taiki YamjiEpidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Yang YangShanghai Pulmonary Hospital, Shanghai, China.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Chen WuDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yun-Chul HongDepartment of Preventive Medicine.
Laurie BurdettCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Gaithersburg, MD, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Kathleen WyattCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Gaithersburg, MD, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Charles C ChungCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Gaithersburg, MD, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Shengchao A LiCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Gaithersburg, MD, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Meredith YeagerCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Gaithersburg, MD, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Amy HutchinsonCancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Gaithersburg, MD, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Wei HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Maria T LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Minsun SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Takashi KohnoDivision of Genome Biology, National Cancer Center Hospital, Tokyo, Japan.
Jun YokotaCancer Genome Biology Group, Institute of Predictive and Personalized Medicine of Cancer, Barcelona, Spain.
Hideo KunitohDepartment of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.
Kyota AshikawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yataro DaigoLaboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Tetsuya MitsudomiDivision of Thoracic Surgery, Kinki University School of Medicine, Sayama, Japan.
Yasushi YatabeDepartment of Pathology and Molecular Diagnostics.
Toyoaki HidaDepartment of Thoracic Oncology, Aichi Cancer Center Central Hospital, Nagoya, Japan.
Zhibin HuDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Juncheng DaiDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Hongxia MaDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Guangfu JinDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Bao SongDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Zhehai WangDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Sensen ChengDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Zhihua YinDepartment of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, China, Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Xuelian LiDepartment of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, China, Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Yangwu RenDepartment of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, China, Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Peng GuanDepartment of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, China, Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Jiang ChangDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wen TanDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chien-Jen ChenGenomic Research Center, Academia Sinica, Taipei, Taiwan.
Gee-Chen ChangFaculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Ying-Huang TsaiDivision of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Wu-Chou SuDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kuan-Yu ChenDivision of Pulmonary Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
Ming-Shyan HuangDepartment of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yuh-Min ChenDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, College of Medical Science and Technology.
Hong ZhengDepartment of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Haixin LiDepartment of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Ping CuiDepartment of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Huan GuoDepartment of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College.
Ping XuDepartment of Oncology, Wuhan Iron and Steel (Group) Corporation Staff-Worker Hospital, Wuhan, China.
Li LiuDepartment of Oncology, Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Motoki IwasakiEpidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Taichi ShimazuEpidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Shoichiro TsuganeEpidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Junjie ZhuShanghai Pulmonary Hospital, Shanghai, China.
Gening JiangShanghai Pulmonary Hospital, Shanghai, China.
Ke FeiShanghai Pulmonary Hospital, Shanghai, China.
Jae Yong ParkLung Cancer Center.
Yeul Hong KimDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Jae Sook SungDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Kyong Hwa ParkDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Young Tae KimDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Yoo Jin JungDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Chang Hyun KangDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
In Kyu ParkDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Hee Nam KimCenter for Creative Biomedical Scientists, Chonnam National University, Gwangju, Republic of Korea.
Hyo-Sung JeonCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Jin Eun ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Yi Young ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Jin Hee KimDepartment of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
In-Jae OhLung and Esophageal Cancer Clinic, Department of Internal Medicine.
Young-Chul KimLung and Esophageal Cancer Clinic, Department of Internal Medicine.
Sook Whan SungDepartment of Thoracic and Cardiovascular Surgery.
Jun Suk KimDepartment of Internal Medicine, Division of Medical Oncology, College of Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
Ho-Il YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Sun-Seog KweonJeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea, Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Adeline SeowSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Ying ChenSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Wei-Yen LimSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Jianjun LiuSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Department of Human Genetics, Genome Institute of Singapore, Singapore, Singapore, School of Life Sciences, Anhui Medical University, Hefei, China.
Maria Pik WongDepartment of Pathology, Li Ka Shing (LKS) Faculty of Medicine.
Victor Ho Fun LeeDepartment of Clinical Oncology, LKS Faculty of Medicine.
Bryan A BassigDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Margaret TuckerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Wong-Ho ChowDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Junwen WangDepartment of Biochemistry, LKS Faculty of Medicine, Centre for Genomic Sciences, LKS Faculty of Medicine.
Jun XuSchool of Public Health, Li Ka Shing (LKS) Faculty of Medicine.
Alan Dart Loon SihoeDepartment of Surgery, Li Ka Shing (LKS) Faculty of Medicine.
James C M HoDepartment of Medicine, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
John K C ChanDepartment of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
Jiu-Cun WangMinistry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Daru LuMinistry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Xueying ZhaoMinistry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Zhenhong ZhaoMinistry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Junjie WuMinistry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Hongyan ChenMinistry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Li JinMinistry of Education Key Laboratory of Contemporary Anthropology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Fusheng WeiChina National Environmental Monitoring Center, Beijing, China.
Guoping WuChina National Environmental Monitoring Center, Beijing, China.
She-Juan AnGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xu-Chao ZhangGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Jian SuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yi-Long WuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Xingzhou HeChinese Center for Disease Control and Prevention, Beijing, China.
Jihua LiQujing Center for Diseases Control and Prevention, Sanjiangdadao, Qujing, China.
Wei ZhengDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
Xiao-Ou ShuDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
Qiuyin CaiDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
Robert KleinProgram in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
William PaoDivision of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Charles LawrenceWestat, Rockville, MD, USA.
H Dean HosgoodDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Chin-Fu HsiaoInstitute of Population Health Sciences.
Li-Hsin ChienInstitute of Population Health Sciences.
Ying-Hsiang ChenInstitute of Population Health Sciences.
Chung-Hsing ChenNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Wen-Chang WangThe PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Division of Thoracic Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan and.
Chih-Liang WangDepartment of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Chong-Jen YuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Hui-Ling ChenInstitute of Population Health Sciences.
Yu-Chun SuInstitute of Population Health Sciences.
Fang-Yu TsaiNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Yi-Song ChenInstitute of Population Health Sciences.
Yao-Jen LiGenomic Research Center, Academia Sinica, Taipei, Taiwan.
Tsung-Ying YangDivision of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Chien-Chung LinDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Pan-Chyr YangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Tangchun WuDepartment of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College.
Dongxin LinDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Baosen ZhouDepartment of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, China, Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Jinming YuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Funding
Molecular Epidemiology Studies of Occupational and Environmental ExposuresZIACP010121 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ROTHMAN, NATHANIEL · 2009 to 2025
$23.5MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MIntramural NIH HHSNCI NIH HHS 1U19CA148127-01NCI NIH HHS U19 CA148127NCI NIH HHS UM1 CA182910
Abstract
Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.
Indexed as
Genetic LociGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAllelesAsian PeopleCase-Control StudiesChromosomes, Human, Pair 12Chromosomes, Human, Pair 6Chromosomes, Human, Pair 9FemaleGenome-Wide Association StudyHumansLung NeoplasmsOdds RatioSmoking
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