SynthesisNeuropsychology review2016
The Combined Effect of Neuropsychological and Neuropathological Deficits on Instrumental Activities of Daily Living in Older Adults: a Systematic Review.
Synthesis in Neuropsychology review, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- The relation between cognitive functioning and activities of daily living in normal aging, mild cognitive impairment, and dementia: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review.Neurosurgical review · 2023Pooled it
- Neighborhood Disadvantage, Functional Difficulty, and Cognitive Decline among Older Mexican Americans.Journal of racial and ethnic health disparities · 2026Article
- IADL for identifying cognitive impairment in Chinese older adults: insights from cross-lagged panel network analysis.BMC geriatrics · 2025Article
- The Moderating Role of Online Awareness in the Association between Strategy Use and Performance Accuracy on a Test of Functional Cognition in Individuals with Acquired Brain Injury.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Observational
- The association between metabolic syndrome components and cognitive function in community-dwelling middle-aged and older adults: the first wave result of a cohort study.Journal of health, population, and nutrition · 2025Article
- A data-driven cluster analysis to explore cognitive reserve and modifiable risk factors in early phases of cognitive decline.Scientific reports · 2025Article
- Longitudinal relationships between depressive symptoms, functional impairment, and physical activity in later late life.GeroScience · 2025Article
- The relationship between intrinsic capacity and functional ability in older adults.BMC geriatrics · 2025Article
- Rethinking neuropsychological test validity in dementia assessment: a critical review in the age of neuroimaging and digital markers.Frontiers in human neuroscience · 2025Review
- Different risk and protective factors predict change of planning ability in middle versus older age.Scientific reports · 2024Article
- Cerebral arteriolosclerosis, lacunar infarcts, and cognition in older Black adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Translation, cross-cultural adaptation and validation of the 10-item Weekly Calendar Planning Activity in Spanish-speaking ABI patients: a multicenter study.Frontiers in psychology · 2023Article
- Changes in executive function in the Canadian longitudinal study on aging over 3-years: A focus on social determinants of health.Frontiers in psychology · 2023Article
- Smartphone-Based Neuropsychological Assessment in Parkinson's Disease: Feasibility, Validity, and Contextually Driven Variability in Cognition.Journal of the International Neuropsychological Society : JINS · 2022Article
- Vascular Cognitive Impairment After Mild Stroke: Connectomic Insights, Neuroimaging, and Knowledge Translation.Frontiers in neuroscience · 2022Review
- Rates of Cognitive and Functional Impairments in Older Adults Residing in a Continuing Care Senior Housing Community.Journal of the International Neuropsychological Society : JINS · 2022Article
- Pathological functional impairment: Neuropsychological correlates of the shared variance between everyday functioning and brain volumetrics.Frontiers in aging neuroscience · 2022Article
- Examining the Academic Trends in Neuropsychological Tests for Executive Functions Using Virtual Reality: Systematic Literature Review.JMIR serious games · 2021Review
- Cognitive reserve relates to executive functioning in the old-old.Aging clinical and experimental research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, studies have consistently demonstrated associations between either neuropsychological deficits or neuroanatomical changes and instrumental activities of daily living (IADL) in aging. Only a limited number of studies have evaluated morphological brain changes and neuropsychological test performance concurrently in relation to IADL in this population. As a result, it remains largely unknown whether these factors independently predict functional outcome. The current systematic review intended to address this lack of information by reviewing the literature on older adults, incorporating studies that examined e.g., normal aging, but also stroke or dementia patients. A comprehensive search of databases (Pubmed, Embase, Medline, Web of Science, PsycINFO) and reference lists was performed, focusing on papers in the English language that examined the combined effect of neuropsychological and neuroanatomical factors on IADL in samples of adults with an average age above 50. In total, 58 potential articles were identified; 20 were included in the review. The results show that especially neuropsychological variables (primarily memory and executive functions) independently predict IADL. Although some unique predictive value of brain morphological changes, such as hippocampal atrophy, was found, support for the importance of white matter changes was limited. However, the results of the studies reviewed are diverse, and appear to be at least partially determined by the variables included. For example, studies were less likely to find an independent effect of cognition if they solely employed a cognitive screening instrument. This indicates that a structured examination of neuroanatomical and neuropsychological correlates of IADL in different patient populations is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.