ArticleJournal of exposure science & environmental epidemiology2017
A systematic evaluation of chemicals in hydraulic-fracturing fluids and wastewater for reproductive and developmental toxicity.
Article in Journal of exposure science & environmental epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Oil and Gas Development and Adverse Birth Outcomes: A Qualitative and Quantitative Bias Analysis of the Epidemiologic Literature.Current environmental health reports · 2026Pooled it
- Systematic review of the association between oil and natural gas extraction processes and human reproduction.Fertility and sterility · 2016Pooled it
- Structural birth defects and exposure to oil and gas wells during pregnancy.Pediatric research · 2026Article
- School-based exposures to oil and gas development for public school children in the United States.Journal of exposure science & environmental epidemiology · 2026Article
- Residential proximity to oil and gas development and risk of gestational diabetes mellitus.International journal of epidemiology · 2026Article
- Using Geoscientific Analysis and Community Engagement to Analyze Exposures to Potential Groundwater Contamination Related to Hydrocarbon Extraction in Southwestern Pennsylvania.Research report (Health Effects Institute) · 2025Article
- High populations near fossil fuel energy infrastructure across the supply chain and implications for an equitable energy transition.Environmental research letters : ERL [Web site] · 2025Article
- IMPACT OF BOOM-AND-BUST ECONOMIES FROM OIL AND GAS DEVELOPMENT ON PSYCHIATRIC HOSPITALIZATIONS AMONG MEDICAID BENEFICIARIES.Environmental research, health : ERH · 2025Article
- Pathways for Potential Exposure to Onshore Oil and Gas Wastewater: What We Need to Know to Protect Human Health.GeoHealth · 2025Review
- A Call for Pediatric Clinicians to Address Environmental Health Concerns in Rural Settings.Pediatric clinics of North America · 2025Review
- Review
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Evidence for reproductive health effects following exposure to hydraulic fracturing chemical mixtures.Reproduction (Cambridge, England) · 2024Review
- Invited Perspective: Drilling Down into the Mechanisms Linking Oil and Gas Development to Adverse Perinatal Health Outcomes.Environmental health perspectives · 2024Article
- Residential Proximity to Oil and Gas Development and Mental Health in a North American Preconception Cohort Study: 2013-2023.American journal of public health · 2024Article
- The human health effects of unconventional oil and gas development (UOGD): A scoping review of epidemiologic studies.Canadian journal of public health = Revue canadienne de sante publique · 2024Article
- In vivo exposure to electronic waste (e-waste) leachate and hydraulic fracturing fluid adversely impacts the male reproductive system.Reproductive toxicology (Elmsford, N.Y.) · 2024Article
- Illegal dumping of oil and gas wastewater alters arid soil microbial communities.Applied and environmental microbiology · 2024Article
- US drinking water quality: exposure risk profiles for seven legacy and emerging contaminants.Journal of exposure science & environmental epidemiology · 2024Review
- Residential proximity to unconventional oil and gas development and birth defects in Ohio.Environmental research · 2023Article
- Social Vulnerability and Groundwater Vulnerability to Contamination From Unconventional Hydrocarbon Extraction in the Appalachian Basin.GeoHealth · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydraulic-fracturing fluids and wastewater from unconventional oil and natural gas development contain hundreds of substances with the potential to contaminate drinking water. Challenges to conducting well-designed human exposure and health studies include limited information about likely etiologic agents. We systematically evaluated 1021 chemicals identified in hydraulic-fracturing fluids (n=925), wastewater (n=132), or both (n=36) for potential reproductive and developmental toxicity to triage those with potential for human health impact. We searched the REPROTOX database using Chemical Abstract Service registry numbers for chemicals with available data and evaluated the evidence for adverse reproductive and developmental effects. Next, we determined which chemicals linked to reproductive or developmental toxicity had water quality standards or guidelines. Toxicity information was lacking for 781 (76%) chemicals. Of the remaining 240 substances, evidence suggested reproductive toxicity for 103 (43%), developmental toxicity for 95 (40%), and both for 41 (17%). Of these 157 chemicals, 67 had or were proposed for a federal water quality standard or guideline. Our systematic screening approach identified a list of 67 hydraulic fracturing-related candidate analytes based on known or suspected toxicity. Incorporation of data on potency, physicochemical properties, and environmental concentrations could further prioritize these substances for future drinking water exposure assessments or reproductive and developmental health studies.
Indexed as
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26732376What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.