ArticleFrontiers in physiology2015
An Ultra-High Field Magnetic Resonance Spectroscopy Study of Post Exercise Lactate, Glutamate and Glutamine Change in the Human Brain.
Article in Frontiers in physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Functional MRS studies of GABA and glutamate/Glx - A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Lactate dynamics in Parkinson's disease: striatal circuit vulnerability, biomarker potential, and therapeutic windows.Molecular medicine (Cambridge, Mass.) · 2026Review
- Iron/cobalt co-doped boron quantum dots as nanozymes with peroxidase-like activities and the nanozyme-involved cascade catalysis system for ratiometric fluorescence and dual-mode visual detection of glutamate.Mikrochimica acta · 2025Article
- Effects of acute physical activity on brain metabolites as measured by magnetic resonance spectroscopy (Heliyon · 2023Article
- Increased brainBiology of sport · 2023Article
- Multinuclear Magnetic Resonance Spectroscopy at Ultra-High-Field: Assessing Human Cerebral Metabolism in Healthy and Diseased States.Metabolites · 2023Review
- Characterization of theJournal of clinical medicine · 2021Article
- Born to move: a review on the impact of physical exercise on brain health and the evidence from human controlled trials.Arquivos de neuro-psiquiatria · 2021Review
- A Randomized Controlled Trial on the Effects of a 12-Week High- vs. Low-Intensity Exercise Intervention on Hippocampal Structure and Function in Healthy, Young Adults.Frontiers in psychiatry · 2021Article
- The Contribution of Functional Magnetic Resonance Imaging to the Understanding of the Effects of Acute Physical Exercise on Cognition.Brain sciences · 2020Review
- Fitness Level Influences White Matter Microstructure in Postmenopausal Women.Frontiers in aging neuroscience · 2020Article
- Determination of acrolein-associated TApplied magnetic resonance · 2019Article
- Inter-Individual Differences in Cognitive Response to a Single Bout of Physical Exercise-A Randomized Controlled Cross-Over Study.Journal of clinical medicine · 2019Article
- Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research.Frontiers in psychology · 2019Article
- Increased Myo-Inositol in Primary Motor Cortex of Contact Sports Athletes without a History of Concussion.Journal of neurotrauma · 2018Article
- GABA concentration in sensorimotor cortex following high-intensity exercise and relationship to lactate levels.The Journal of physiology · 2018Article
- The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- Increases in BrainFrontiers in physiology · 2017Article
- Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment.Frontiers in human neuroscience · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
During strenuous exercise there is a progressive increase in lactate uptake and metabolism into the brain as workload and plasma lactate levels increase. Although it is now widely accepted that the brain can metabolize lactate, few studies have directly measured brain lactate following vigorous exercise. Here, we used ultra-high field magnetic resonance spectroscopy of the brain to obtain static measures of brain lactate, as well as brain glutamate and glutamine after vigorous exercise. The aims of our experiment were to (a) track the changes in brain lactate following recovery from exercise, and (b) to simultaneously measure the signals from brain glutamate and glutamine. The results of our experiment showed that vigorous exercise resulted in a significant increase in brain lactate. Furthermore, both glutamate and glutamine were successfully resolved, and as expected, although contrary to some previous reports, we did not observe any significant change in either amino acid after exercise. We did however observe a negative correlation between glutamate and a measure of fitness. These results support the hypothesis that peripherally derived lactate is taken up by the brain when available. Our data additionally highlight the potential of ultra-high field MRS as a non-invasive way of measuring multiple brain metabolite changes with exercise.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.