Evidence map›Paper›PMID 26732146›Full record

SynthesisBMC infectious diseases2016

A systematic review of reported reassortant viral lineages of influenza A.

Amy Pinsent, Christophe Fraser, Neil M Ferguson, Steven Riley

Abstract readSystematic Review
In one paragraph

Synthesis in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Improving risk assessment of the emergence of novel influenza A viruses by incorporating environmental surveillance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amy PinsentDepartment of Infectious Disease Epidemiology, MRC Centre for Outbreak Analyses and Modelling, School of Public Health, Imperial College London, London, UK. amy.pinsent07@imperial.ac.uk.
Christophe FraserDepartment of Infectious Disease Epidemiology, MRC Centre for Outbreak Analyses and Modelling, School of Public Health, Imperial College London, London, UK. c.fraser@imperial.ac.uk.
Neil M FergusonDepartment of Infectious Disease Epidemiology, MRC Centre for Outbreak Analyses and Modelling, School of Public Health, Imperial College London, London, UK. n.ferguson@imperial.ac.uk.
Steven RileyDepartment of Infectious Disease Epidemiology, MRC Centre for Outbreak Analyses and Modelling, School of Public Health, Imperial College London, London, UK. s.riley@imperial.ac.uk.

Funding

Models for synthesising molecular, clinical and epidemiological data, and translaU01GM110721 · NIGMS · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI CAUCHEMEZ, SIMON, FERGUSON, NEIL MORRIS · 2014 to 2018
$1.9M
Ecology of Infectious Diseases (EID)-Immune Landscapes of Human Influenza in HousR01TW008246 · FIC · JOHNS HOPKINS UNIVERSITY · PI CUMMINGS, DEREK A · 2008 to 2011
$1.9M
FIC NIH HHS R01 TW008246FIC NIH HHS R01 TW008246-01Medical Research Council MR/J008761/1Medical Research Council MR/K010174/1NIGMS NIH HHS U01 GM110721NIGMS NIH HHS U01 GM110721-01Wellcome TrustWellcome Trust 093488/Z/10/Z
6 · The paper itself

Abstract

backgroundMost previous evolutionary studies of influenza A have focussed on genetic drift, or reassortment of specific gene segments, hosts or subtypes. We conducted a systematic literature review to identify reported claimed reassortant influenza A lineages with genomic data available in GenBank, to obtain 646 unique first-report isolates out of a possible 20,781 open-access genomes.

resultsAfter adjusting for correlations, only: swine as host, China, Europe, Japan and years between 1997 and 2002; remained as significant risk factors for the reporting of reassortant viral lineages. For swine H1, more reassortants were observed in the North American H1 clade compared with the Eurasian avian-like H1N1 clade. Conversely, for avian H5 isolates, a higher number of reported reassortants were observed in the European H5N2/H3N2 clade compared with the H5N2 North American clade.

conclusionsDespite unavoidable biases (publication, database choice and upload propensity) these results synthesize a large majority of the current literature on novel reported influenza A reassortants and are a potentially useful prerequisite to inform further algorithmic studies.

Indexed as

AnimalsGenetic DriftHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza A Virus, H5N2 SubtypeInfluenza, HumanPhylogenyReassortant Viruses

Identifiers

PMID26732146
PMCPMC4702296

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.