ArticleFrontiers in psychiatry2015
Large-Scale Fusion of Gray Matter and Resting-State Functional MRI Reveals Common and Distinct Biological Markers across the Psychosis Spectrum in the B-SNIP Cohort.
Article in Frontiers in psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.Molecular neurobiology · 2018Pooled it
- An Introduction to the Human Connectome Project for Early Psychosis.Schizophrenia bulletin · 2025Article
- Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum.Frontiers in psychiatry · 2025Article
- Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder.BMC psychiatry · 2023Article
- The Risk for Schizophrenia-Bipolar Spectrum: Does the Apple Fall Close to the Tree? A Narrative Review.International journal of environmental research and public health · 2023Review
- Data-driven multimodal fusion: approaches and applications in psychiatric research.Psychoradiology · 2023Review
- Mapping relationships among schizophrenia, bipolar and schizoaffective disorders: A deep classification and clustering framework using fMRI time series.Schizophrenia research · 2022Article
- The critical periods of cerebral plasticity: A key aspect in a dialog between psychoanalysis and neuroscience centered on the psychopathology of schizophrenia.Frontiers in molecular neuroscience · 2022Article
- Multimodal MRI assessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup.Human brain mapping · 2021Article
- Addressing Inaccurate Nosology in Mental Health: A Multilabel Data Cleansing Approach for Detecting Label Noise From Structural Magnetic Resonance Imaging Data in Mood and Psychosis Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Patient, interrupted: MEG oscillation dynamics reveal temporal dysconnectivity in schizophrenia.NeuroImage. Clinical · 2020Article
- Four-way multimodal fusion of 7 T imaging data using an mCCA+jICA model in first-episode schizophrenia.Human brain mapping · 2018Article
- Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury.Neural regeneration research · 2017Article
- Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: Modeling head motion and neuroanatomical specificity.Human brain mapping · 2017Article
- Aberrant cerebellar connectivity in bipolar disorder with psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Neurobiological Evidence for the Primacy of Mania Hypothesis.Current neuropharmacology · 2017Review
- On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis.Human brain mapping · 2017Article
- From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia.Frontiers in neuroscience · 2016Review
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
To investigate whether aberrant interactions between brain structure and function present similarly or differently across probands with psychotic illnesses [schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar I disorder with psychosis (BP)] and whether these deficits are shared with their first-degree non-psychotic relatives. A total of 1199 subjects were assessed, including 220 SZ, 147 SAD, 180 psychotic BP, 150 first-degree relatives of SZ, 126 SAD relatives, 134 BP relatives, and 242 healthy controls (1). All subjects underwent structural MRI (sMRI) and resting-state functional MRI (rs-fMRI) scanning. Joint-independent component analysis (jICA) was used to fuse sMRI gray matter and rs-fMRI amplitude of low-frequency fluctuations data to identify the relationship between the two modalities. jICA revealed two significantly fused components. The association between functional brain alteration in a prefrontal-striatal-thalamic-cerebellar network and structural abnormalities in the default mode network was found to be common across psychotic diagnoses and correlated with cognitive function, social function, and schizo-bipolar scale scores. The fused alteration in the temporal lobe was unique to SZ and SAD. The above effects were not seen in any relative group (including those with cluster-A personality). Using a multivariate-fused approach involving two widely used imaging markers, we demonstrate both shared and distinct biological traits across the psychosis spectrum. Furthermore, our results suggest that the above traits are psychosis biomarkers rather than endophenotypes.
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Registered trials
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