ReviewAsian journal of andrology
Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation.
Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03835143 (the Effect of Sub-inguinal Varicocelectomy in Patients Complaining of Orchialgia With Normal Semen Analysis), which is not on this map. Cited by 116 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
the Effect of Sub-inguinal Varicocelectomy in Patients Complaining of Orchialgia With Normal Semen Analysis
Who cites it
116 citing papers in PubMed, 2 syntheses or guidelines pooled it, 265 citations in OpenAlex.
- Don't wait any longer, conceive in time: a systematic review and meta-analysis based on semen parameters after varicocelectomy.International urology and nephrology · 2024Pooled it
- Influence of Varicocelectomy on Assisted Reproductive Technology Outcomes of Infertile Patients with Varicocele: A Systematic Review and Meta-Analysis.American journal of men's healthPooled it
- The role of the mitochondrial injury-mediated oxidative stress-sterile inflammation axis in varicocele-induced infertility: a narrative review.Basic and clinical andrology · 2026Review
- USP2 Attenuates Spermatogenic Cell Apoptosis Via PINK1/Parkin-Dependent Mitophagy in Varicocoele: A Functional Study.Andrology · 2026Article
- Varicocelectomy Restores Spermatogenesis in Fontan-Associated Varicocele: A Two-Case Series.IJU case reports · 2026Article
- Sperm DNA Fragmentation in Men with Varicocele: A Systematic Review and Meta-Analysis.The world journal of men's health · 2026Article
- Optimized Formulation of Sulfasalazine and Probiotic-Loaded Carrageenan Microparticles Using Design of Experiments for Effective Colitis Management.Recent advances in drug delivery and formulation · 2026Article
- Mechanistic insights into the potential role of botanical drugs and plant-derived metabolites in mitigating oxidative stress in varicocele.Frontiers in pharmacology · 2026Review
- Evaluating Sperm DNA Damage: When and Why It Does Not Add to the Evaluation of Male Factor Infertility.Advances in experimental medicine and biology · 2026Review
- Sperm DNA integrity and sexual dysfunction among infertile men : DFI and sexual dysfunction.Journal of assisted reproduction and genetics · 2026Article
- N-acetylcysteine Improved Expression of FSHR, LHCGR, Catsper-1, Catsper-2, and SF-1 Genes in Testis of Rats with Varicocele.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Risk factors associated with varicocele: a narrative review.Translational andrology and urology · 2025Review
- Ferroptotic- and non-ferroptotic mechanisms associated with doxorubicin-induced male reproductive dysfunction.Toxicology reports · 2025Review
- Role of varicocelectomy in infertile patients with clinical varicocele and isolated sperm defects.Asian journal of urology · 2025Article
- Research advances in inflammation and oxidative stress in varicocele-induced male infertility: a narrative review.Asian journal of andrology · 2025Review
- Comparison of fresh testicular sperm aspiration and use of either thawed pre-frozen sperm or oocyte freezing: impact on cumulative live birth rates for couples experiencing ejaculation failure.Human reproduction (Oxford, England) · 2025Article
- Impact of Varicocele on The Expression of Testicular Enzymes Involved in The Transsulfuration Pathway.International journal of fertility & sterility · 2025Article
- The mechanism of oxidative stress in asthenozoospermia and antioxidant strategies: a review.Frontiers in endocrinology · 2025Review
- Sperm DNA Fragmentation and Fertility.Advances in experimental medicine and biology · 2025Review
- Involvement of autophagy in germ cells in an experimental model of varicocele in rats before and after varicocelectomy.Pediatric surgery international · 2024Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Varicocele has been associated with reduced male reproductive potential. With the advances in biomolecular techniques, it has been possible to better understand the mechanisms involved in testicular damage provoked by varicocele. Current evidence suggests the central role of reactive oxygen species (ROS) and the resultant oxidative stress (OS) in the pathogenesis of varicocele-associated male subfertility although the mechanisms have not yet been fully described and it is likely to be multifactorial. Excessive ROS is associated with sperm DNA fragmentation, which may mediate the clinical manifestation of poor sperm function and fertilization outcome related to varicocele. Testing of ROS/OS and DNA fragmentation has the potential to provide additional diagnostic and prognostic information compared to conventional semen analysis and may guide therapeutic management strategies in individual patient.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.