Evidence map›Paper›PMID 26732045›Full record

ArticleTuberculosis (Edinburgh, Scotland)2016

Pulmonary responses to pathogen-specific antigens in latent Mycobacterium tuberculosis infection.

Jessica R Jarvela, Lori Tuscano, Hung Lee, Richard F Silver

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tuberculosis (Edinburgh, Scotland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Lung Resident T Cells Across the Spectrum of TB Infection and Disease.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. iScience · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica R JarvelaDivision of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes Cleveland Department of Veterans' Affairs Medical Center, Cleveland, OH, USA.
Lori TuscanoDivision of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes Cleveland Department of Veterans' Affairs Medical Center, Cleveland, OH, USA.
Hung LeeDivision of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes Cleveland Department of Veterans' Affairs Medical Center, Cleveland, OH, USA.
Richard F SilverDivision of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Division of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes Cleveland Department of Veterans' Affairs Medical Center, Cleveland, OH, USA. Electronic address: rfs4@case.edu.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Expression signatures of TB-specific memory responses within the human lungR01HL111523 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SILVER, RICHARD F · 2013 to 2018
$2.6M
NCRR NIH HHS UL1 RR024989NHLBI NIH HHS R01 HL111523NHLBI NIH HHS R01-HL111523
6 · The paper itself

Abstract

In this study, we used ELISPOT to quantify frequencies of bronchoalveolar lavage (BAL) and peripheral blood T cells capable of producing IFNγ in response to PPD, antigen 85B, and Mtb-specific antigens CFP-10 and ESAT-6 in individuals with latent tuberculosis infection (LTBI) and Mtb-naïve controls. Compared to peripheral blood, BAL cells of LTBI subjects displayed significant enrichment for T cells responding to PPD, antigen 85B, and CFP-10, but not to ESAT-6. Baseline BAL cells of LTBI subjects displayed significant production of Mig (CXCL9) in response to PPD, antigen 85B, and CFP-10 as well. These findings suggest that enrichment for Mtb-specific T cells within BAL is not unique to active pulmonary tuberculosis and may, to the contrary, contribute to protection from re-infection in Mtb immune individuals.

Indexed as

AcyltransferasesAdultAntigens, BacterialBacterial ProteinsBronchoalveolar Lavage FluidCase-Control StudiesCells, CulturedChemokine CXCL10Chemokine CXCL9Enzyme-Linked Immunospot AssayFemaleHost-Pathogen InteractionsHumansInterferon-gammaInterferon-gamma Release TestsLatent TuberculosisAcyltransferasesantigen 85B, Mycobacterium tuberculosisAntigens, BacterialBacterial ProteinsCFP-10 protein, Mycobacterium tuberculosisChemokine CXCL10Chemokine CXCL9CXCL10 protein, humanCXCL9 protein, humanESAT-6 protein, Mycobacterium tuberculosisIFNG protein, humanInterferon-gammaTuberculinBronchoalveolar lavageELISPOTImmunodiagnosisLatent tuberculosis infectionTuberculosis

Identifiers

PMID26732045
PMCPMC6726121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.