ArticleJMIR research protocols2016
Collecting Biospecimens From an Internet-Based Prospective Cohort Study of Inflammatory Bowel Disease (CCFA Partners): A Feasibility Study.
Article in JMIR research protocols, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research.BMC complementary and alternative medicine · 2019Trial
- Feasibility of mailed biomarker data collection among U.S. young adults: Saliva-based cotinine and self-reported nicotine use.Drug and alcohol dependence · 2023Article
- Nucleic acid adductomics - The next generation of adductomics towards assessing environmental health risks.The Science of the total environment · 2023Article
- Feasibility of mail-based biospecimen collection in an online preconception cohort study.Frontiers in reproductive health · 2022Article
- Patient-Powered Research Networks of the Autoimmune Research Collaborative: Rationale, Capacity, and Future Directions.The patient · 2021Article
- Delivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial.Lupus science & medicine · 2021Article
- Seeing Is Believing? Unique Capabilities of Internet-Only Studies as a Tool for Implementation Research on HIV Prevention for Men Who Have Sex With Men: A Review of Studies and Methodological Considerations.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Urinary DNA adductomics - A novel approach for exposomics.Environment international · 2018Article
- Feasibility of salivary DNA collection in a population-based case-control study: a pilot study of pediatric Crohn's disease.Clinical epidemiology · 2018Article
- The Saliva Exposome for Monitoring of Individuals' Health Trajectories.Environmental health perspectives · 2017Article
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Authors and funding
14 authors.
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Abstract
backgroundThe Internet has successfully been used for patient-oriented survey research. Internet-based translational research may also be possible.
objectiveOur aim was to study the feasibility of collecting biospecimens from CCFA Partners, an Internet-based inflammatory bowel disease (IBD) cohort.
methodsFrom August 20, 2013, to January 4, 2014, we randomly sampled 412 participants, plus 179 from a prior validation study, and invited them to contribute a biospecimen. Participants were randomized to type (blood, saliva), incentive (none, US $20, or US $50), and collection method for blood. The first 82 contributors were also invited to contribute stool. We used descriptive statistics and t tests for comparisons.
resultsOf the 591 participants, 239 (40.4%) indicated interest and 171 (28.9%) contributed a biospecimen. Validation study participants were more likely to contribute than randomly selected participants (44% versus 23%, P<.001). The return rate for saliva was higher than blood collected by mobile phlebotomist and at doctors' offices (38%, 31%, and 17% respectively, P<.001). For saliva, incentives were associated with higher return rates (43-44% versus 26%, P=.04); 61% contributed stool. Fourteen IBD-associated single nucleotide polymorphisms were genotyped, and risk allele frequencies were comparable to other large IBD populations. Bacterial DNA was successfully extracted from stool samples and was of sufficient quality to permit quantitative polymerase chain reaction for total bacteria.
conclusionsParticipants are willing to contribute and it is feasible to collect biospecimens from an Internet-based IBD cohort. Home saliva kits yielded the highest return rate, though mobile phlebotomy was also effective. All samples were sufficient for genetic testing. These data support the feasibility of developing a centralized collection of biospecimens from this cohort to facilitate IBD translational studies.
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