ArticleHeredity2016
Direct and indirect genetic effects of sex-specific mitonuclear epistasis on reproductive ageing.
Article in Heredity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Testing the Mother's Curse Hypothesis in Human Mitochondrial Genome Evolution.Genome biology and evolution · 2025Article
- Article
- Sex-Specific Dominance of Gene Expression in Seed Beetles.Molecular biology and evolution · 2024Article
- Mitonuclear effects on sex ratio persist across generations in interpopulation hybrids.Journal of evolutionary biology · 2024Article
- Mother's Curse effects on lifespan and aging.Frontiers in aging · 2024Review
- Mapping mitonuclear epistasis using a novel recombinant yeast population.PLoS genetics · 2023Article
- Mitochondrial effects on fertility and longevity inProceedings. Biological sciences · 2022Article
- Mother's curse is pervasive across a large mitonuclearEvolution letters · 2021Article
- Female-specific resource limitation does not make the opportunity for selection more female biased.Evolution; international journal of organic evolution · 2020Article
- An experimental test of temperature-dependent selection on mitochondrial haplotypes inEcology and evolution · 2020Article
- Sibling rivalry versus mother's curse: can kin competition facilitate a response to selection on male mitochondria?Proceedings. Biological sciences · 2020Article
- Mitonuclear genomics and aging.Human genetics · 2020Review
- Nutritional geometry of mitochondrial genetic effects on male fertility.Biology letters · 2020Article
- Review
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- The cuticle inward barrier inPeerJ · 2019Article
- Mitochondrial genetic effects on reproductive success: signatures of positive intrasexual, but negative intersexual pleiotropy.Proceedings. Biological sciences · 2018Article
- Coadaptation of mitochondrial and nuclear genes, and the cost of mother's curse.Proceedings. Biological sciences · 2018Article
- Evolution of sex-specific pace-of-life syndromes: genetic architecture and physiological mechanisms.Behavioral ecology and sociobiology · 2018Review
- The Evolution of Dark Matter in the Mitogenome of Seed Beetles.Genome biology and evolution · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Mitochondria are involved in ageing and their function requires coordinated action of both mitochondrial and nuclear genes. Epistasis between the two genomes can influence lifespan but whether this also holds for reproductive senescence is unclear. Maternal inheritance of mitochondria predicts sex differences in the efficacy of selection on mitonuclear genotypes that should result in differences between females and males in mitochondrial genetic effects. Mitonuclear genotype of a focal individual may also indirectly affect trait expression in the mating partner. We tested these predictions in the seed beetle Callosobruchus maculatus, using introgression lines harbouring distinct mitonuclear genotypes. Our results reveal both direct and indirect sex-specific effects of mitonuclear epistasis on reproductive ageing. Females harbouring coadapted mitonuclear genotypes showed higher lifetime fecundity due to slower senescence relative to novel mitonuclear combinations. We found no evidence for mitonuclear coadaptation in males. Mitonuclear epistasis not only affected age-specific ejaculate weight, but also influenced male age-dependent indirect effects on traits expressed by their female partners (fecundity, egg size, longevity). These results demonstrate important consequences of sex-specific mitonuclear epistasis for both mating partners, consistent with a role for mitonuclear genetic constraints upon sex-specific adaptive evolution.
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